ARHGAP10 (Rho GTPase activating protein 10)

2006-10-01 Affiliation

Identity

HGNC

ARHGAP10

LOCATION

4q31.23

LOCUSID

79658

ALIAS

GRAF2,PS-GAP,PSGAP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 79658
MIM: 609746
HGNC: 26099
Ensembl: ENSG00000071205

Variants:

dbSNP: 79658
ClinVar: 79658
TCGA: ENSG00000071205
COSMIC: ARHGAP10

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000071205	ENST00000336498	A1A4S6
ENSG00000071205	ENST00000336498	A0A2X0SFB3
ENSG00000071205	ENST00000507661	H0Y8W5

Expression (GTEx)

100

150

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Bacterial invasion of epithelial cells	KEGG	ko05100
Bacterial invasion of epithelial cells	KEGG	hsa05100
Signal Transduction	REACTOME	R-HSA-162582
Signaling by Rho GTPases	REACTOME	R-HSA-194315
Rho GTPase cycle	REACTOME	R-HSA-194840
Programmed Cell Death	REACTOME	R-HSA-5357801
Apoptosis	REACTOME	R-HSA-109581
Regulation of Apoptosis	REACTOME	R-HSA-169911
Regulation of PAK-2p34 activity by PS-GAP/RHG10	REACTOME	R-HSA-211728

References

Pubmed ID	Year	Title	Citations
31789419	2020	miR‑337‑3p inhibits gastric tumor metastasis by targeting ARHGAP10.	13
32344433	2020	GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.	17
32699248	2020	ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.	24
31789419	2020	miR‑337‑3p inhibits gastric tumor metastasis by targeting ARHGAP10.	13
32344433	2020	GRAF2, WDR44, and MICAL1 mediate Rab8/10/11-dependent export of E-cadherin, MMP14, and CFTR ΔF508.	17
32699248	2020	ARHGAP10, which encodes Rho GTPase-activating protein 10, is a novel gene for schizophrenia risk.	24
31445707	2019	CXCL12 promotes human ovarian cancer cell invasion through suppressing ARHGAP10 expression.	8
31445707	2019	CXCL12 promotes human ovarian cancer cell invasion through suppressing ARHGAP10 expression.	8
27010858	2016	ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells.	38
27010858	2016	ARHGAP10, downregulated in ovarian cancer, suppresses tumorigenicity of ovarian cancer cells.	38
19911011	2010	Mutation of ARHGAP9 in patients with coronary spastic angina.	0
20158304	2010	A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations.	55
20332263	2010	A genome-wide association study of prognosis in breast cancer.	46
20379614	2010	Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.	78
19911011	2010	Mutation of ARHGAP9 in patients with coronary spastic angina.	0

Citation

Dessen P

ARHGAP10 (Rho GTPase activating protein 10)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43130/css/lib/gene-fusions-explorer/humanGenome