CDC5L (cell division cycle 5 like)

2006-10-01  

Identity

HGNC
LOCATION
6p21.1
LOCUSID
ALIAS
CDC5,CDC5-LIKE,CEF1,PCDC5RP,dJ319D22.1
FUSION GENES

Other Information

Locus ID:

NCBI: 988
MIM: 602868
HGNC: 1743
Ensembl: ENSG00000096401

Variants:

dbSNP: 988
ClinVar: 988
TCGA: ENSG00000096401
COSMIC: CDC5L

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000096401ENST00000371477Q99459

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Spliceosome, Prp19/CDC5L complexKEGGhsa_M00353
Spliceosome, 35S U5-snRNPKEGGhsa_M00355
Spliceosome, Prp19/CDC5L complexKEGGM00353
Spliceosome, 35S U5-snRNPKEGGM00355
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA445218Pancreatic NeoplasmsDiseaseClinicalAnnotationassociatedPD22838950
PA449748gemcitabineChemicalClinicalAnnotationassociatedPD22838950

References

Pubmed IDYearTitleCitations
342980172021CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1.6
349031392021Downregulation of DEAD-box helicase 21 (DDX21) inhibits proliferation, cell cycle, and tumor growth in colorectal cancer via targeting cell division cycle 5-like (CDC5L).3
342980172021CDC5L promotes early chondrocyte differentiation and proliferation by modulating pre-mRNA splicing of SOX9, COL2A1, and WEE1.6
349031392021Downregulation of DEAD-box helicase 21 (DDX21) inhibits proliferation, cell cycle, and tumor growth in colorectal cancer via targeting cell division cycle 5-like (CDC5L).3
325267062020ANXA7 promotes the cell cycle, proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L.7
325267062020ANXA7 promotes the cell cycle, proliferation and cell adhesion-mediated drug resistance of multiple myeloma cells by up-regulating CDC5L.7
298719352018Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L-AGRN Transcriptional Regulation Circuit.53
298719352018Oncogenic Properties of NEAT1 in Prostate Cancer Cells Depend on the CDC5L-AGRN Transcriptional Regulation Circuit.53
283877152017Prp19 Arrests Cell Cycle via Cdc5L in Hepatocellular Carcinoma Cells.10
283877152017Prp19 Arrests Cell Cycle via Cdc5L in Hepatocellular Carcinoma Cells.10
264909802016Expression of CDC5L is associated with tumor progression in gliomas.14
265532512016Expression and Clinical Role of Cdc5L as a Novel Cell Cycle Protein in Hepatocellular Carcinoma.15
264909802016Expression of CDC5L is associated with tumor progression in gliomas.14
265532512016Expression and Clinical Role of Cdc5L as a Novel Cell Cycle Protein in Hepatocellular Carcinoma.15
261307212015CTNNBL1 facilitates the association of CWC15 with CDC5L and is required to maintain the abundance of the Prp19 spliceosomal complex.7

Citation

Dessen P

CDC5L (cell division cycle 5 like)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43199/css/deep-insight-explorer/haematological-explorer/