CIT (citron rho-interacting serine/threonine kinase)

2006-10-01  

Identity

HGNC
CIT
LOCATION
12q24.23
LOCUSID
11113
ALIAS
CITK,CRIK,MCPH17,STK21
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 11113
MIM: 605629
HGNC: 1985
Ensembl: ENSG00000122966

Variants:

dbSNP: 11113
ClinVar: 11113
TCGA: ENSG00000122966
COSMIC: CIT

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000122966ENST00000261833O14578
ENSG00000122966ENST00000392520H7BYJ3
ENSG00000122966ENST00000392521O14578
ENSG00000122966ENST00000536325H0YGG8
ENSG00000122966ENST00000546026F5H4K4
ENSG00000122966ENST00000612548O14578

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases activate CITREACTOMER-HSA-5625900

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378016132023Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase.2
378016132023Prostate Cancer Progression Relies on the Mitotic Kinase Citron Kinase.2
319723592020Down-regulation of CIT can inhibit the growth of human bladder cancer cells.9
327051612020Novel circRNA_0071196/miRNA‑19b‑3p/CIT axis is associated with proliferation and migration of bladder cancer.11
319723592020Down-regulation of CIT can inhibit the growth of human bladder cancer cells.9
327051612020Novel circRNA_0071196/miRNA‑19b‑3p/CIT axis is associated with proliferation and migration of bladder cancer.11
305650872019Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism.9
309406342019Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma.10
305650872019Citron kinase (CIT-K) promotes aggressiveness and tumorigenesis of breast cancer cells in vitro and in vivo: preliminary study of the underlying mechanism.9
309406342019Citron Rho-interacting kinase silencing causes cytokinesis failure and reduces tumor growth in multiple myeloma.10
299216972018Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence.17
299216972018Inactivation of Citron Kinase Inhibits Medulloblastoma Progression by Inducing Apoptosis and Cell Senescence.17
265865742016Tissue-specific control of midbody microtubule stability by Citron kinase through modulation of TUBB3 phosphorylation.26
270091912016Cross-regulation between Aurora B and Citron kinase controls midbody architecture in cytokinesis.26
274535782016Biallelic Mutations in Citron Kinase Link Mitotic Cytokinesis to Human Primary Microcephaly.45

Citation

Dessen P

CIT (citron rho-interacting serine/threonine kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43214/js/favicon/gene-explorer/