DYRK1B (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B)

2008-05-01   Eileen Friedman  

Upstate Medical University, State University of New York, Syracuse, New York 13210, USA

Identity

HGNC
DYRK1B
LOCATION
19q13.2
LOCUSID
9149
ALIAS
AOMS3,MIRK
FUSION GENES
Show Gene Fusions

DNA/RNA

Description

11 exons and 10 introns encompassing 8.8kb.

Transcription

Start at exon 1 encodes major active form p69, with alternative splicing in exon 9 giving rise to kinase inactive p62, and with alternative splicing within intron 1-2 giving rise to p75 in skeletal muscle.

Pseudogene

None reported

Proteins

Note

Serine/threonine kinase activated by intramolecular phosphorylation on tyrosine.

Description

629 amino acids.

Expression

Widely expressed at low levels, with elevated expression in muscle and testis.

Function

Mediates myoblast differentiation.

Mutations

Note

None in SW480 colon cancer cells, none reported.

Implicated in

Entity name
Ductal adenocarcinoma of the pancreas
Note
Active kinase in pancreatic cancer cell lines.
Disease
Present in 89% of cases by immunocytochemistry (25 of 28 cases)
Cytogenetics
19q13 amplicon in 10% of cases
Hybrid gene
None reported
Fusion protein
None reported
Oncogenesis
Embryonic knockout is viable and has no reported phenotype
Entity name
Rhabdomyosarcoma
Note
Overexpressed in 12 of 16 cases; active kinase in rhabdomyosarcoma cell lines

Article Bibliography

Pubmed IDLast YearTitleAuthors
166187362006The kinase Mirk/Dyrk1B mediates cell survival in pancreatic ductal adenocarcinoma.Deng X et al
176711932007The survival kinase Mirk/Dyrk1B is a downstream effector of oncogenic K-ras in pancreatic cancer.Jin K et al
109100782000Mirk protein kinase is a mitogen-activated protein kinase substrate that mediates survival of colon cancer cells.Lee K et al
167074372006Mirk/Dyrk1b mediates cell survival in rhabdomyosarcomas.Mercer SE et al

Other Information

Locus ID:

NCBI: 9149
MIM: 604556
HGNC: 3092
Ensembl: ENSG00000105204

Variants:

dbSNP: 9149
ClinVar: 9149
TCGA: ENSG00000105204
COSMIC: DYRK1B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000105204ENST00000323039Q9Y463
ENSG00000105204ENST00000323039A0A024R0I0
ENSG00000105204ENST00000348817Q9Y463
ENSG00000105204ENST00000348817A0A024R0M8
ENSG00000105204ENST00000430012Q9Y463
ENSG00000105204ENST00000430012A0A024R0J6
ENSG00000105204ENST00000593685Q9Y463
ENSG00000105204ENST00000593685A0A024R0I0
ENSG00000105204ENST00000597639Q9Y463
ENSG00000105204ENST00000597639A0A024R0M8
ENSG00000105204ENST00000600611M0R131
ENSG00000105204ENST00000601972M0R2X3

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
380401232024Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance.1
381709572024Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.1
380401232024Targeting the survival kinase DYRK1B: A novel approach to overcome radiotherapy-related treatment resistance.1
381709572024Pathogenic, Total Loss-of-Function DYRK1B Variants Cause Monogenic Obesity Associated With Type 2 Diabetes.1
349697682022Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.1
351653642022Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.3
352353432022DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.42
363184892022Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis.2
349697682022Suppression of DYRK1A/B Drives Endoplasmic Reticulum Stress-mediated Autophagic Cell Death Through Metabolic Reprogramming in Colorectal Cancer Cells.1
351653642022Differential maturation and chaperone dependence of the paralogous protein kinases DYRK1A and DYRK1B.3
352353432022DYRK1B-STAT3 Drives Cardiac Hypertrophy and Heart Failure by Impairing Mitochondrial Bioenergetics.42
363184892022Analysis of DYRK1B, PPARG, and CEBPB Expression Patterns in Adipose-Derived Stem Cells from Patients Carrying DYRK1B R102C and Healthy Individuals During Adipogenesis.2
342913932021Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.1
342913932021Study of DYRK1B gene expression and its association with metabolic syndrome in a small cohort of Egyptians.1
326118152020Screen identifies DYRK1B network as mediator of transcription repression on damaged chromatin.6

Citation

Eileen Friedman

DYRK1B (dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B)

Atlas Genet Cytogenet Oncol Haematol. 2008-05-01

Online version: http://atlasgeneticsoncology.org/gene/43235/case-report-explorer/tumors-explorer/js/web-card-_common.js