EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4)

2006-10-01  

Identity

HGNC
EIF2AK4
LOCATION
15q15.1
LOCUSID
440275
ALIAS
GCN2,PVOD2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 440275
MIM: 609280
HGNC: 19687
Ensembl: ENSG00000128829

Variants:

dbSNP: 440275
ClinVar: 440275
TCGA: ENSG00000128829
COSMIC: EIF2AK4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000128829ENST00000263791Q9P2K8
ENSG00000128829ENST00000558823H0YNY9
ENSG00000128829ENST00000559624Q9P2K8
ENSG00000128829ENST00000560648H0YND8
ENSG00000128829ENST00000560855H0YME5

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Autophagy - animalKEGGko04140
Autophagy - animalKEGGhsa04140
Protein processing in endoplasmic reticulumKEGGko04141
Protein processing in endoplasmic reticulumKEGGhsa04141
Hepatitis CKEGGko05160
Hepatitis CKEGGhsa05160
MeaslesKEGGko05162
MeaslesKEGGhsa05162
Influenza AKEGGko05164
Influenza AKEGGhsa05164
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Epstein-Barr virus infectionKEGGhsa05169
Epstein-Barr virus infectionKEGGko05169

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA447216SchizophreniaDiseaseClinicalAnnotationassociatedPD24751813
PA449841haloperidolChemicalClinicalAnnotation, MultilinkAnnotationassociatedPD24751813, 27023437
PA450688olanzapineChemicalClinicalAnnotationassociatedPD24751813
PA451201quetiapineChemicalClinicalAnnotationassociatedPD24751813
PA451257risperidoneChemicalClinicalAnnotationassociatedPD24751813
PA451974ziprasidoneChemicalClinicalAnnotationassociatedPD24751813

References

Pubmed IDYearTitleCitations
381757552024Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes.2
382811372024Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions.1
381757552024Downregulation of nutrition sensor GCN2 in macrophages contributes to poor wound healing in diabetes.2
382811372024Multiple mechanisms activate GCN2 eIF2 kinase in response to diverse stress conditions.1
364761912023Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis.4
366333832023A new mutation in the EIF2AK4 gene in familial pulmonary veno-occlusive disease.1
369017142023Multiple Roles of the Stress Sensor GCN2 in Immune Cells.5
370175292023Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction.1
371996442023Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival.0
364761912023Disruption of GCN2 Pathway Aggravates Vascular and Parenchymal Remodeling during Pulmonary Fibrosis.4
366333832023A new mutation in the EIF2AK4 gene in familial pulmonary veno-occlusive disease.1
369017142023Multiple Roles of the Stress Sensor GCN2 in Immune Cells.5
370175292023Contributions of Ccr4 and Gcn2 to the Translational Response of C. neoformans to Host-Relevant Stressors and Integrated Stress Response Induction.1
371996442023Hepatitis E Virus Protease Inhibits the Activity of Eukaryotic Initiation Factor 2-Alpha Kinase 4 and Promotes Virus Survival.0
351374492022Amino acid restriction induces a long non-coding RNA UBA6-AS1 to regulate GCN2-mediated integrated stress response in breast cancer.6

Citation

Dessen P

EIF2AK4 (eukaryotic translation initiation factor 2 alpha kinase 4)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43241/gene-explorer/css/deep-insight-explorer/