EPHA6 (EPH receptor A6)

2006-10-01  

Identity

HGNC
EPHA6
LOCATION
3q11.2
LOCUSID
285220
ALIAS
EHK-2,EHK2,EK12,EPA6,HEK12,PRO57066
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 285220
MIM: 600066
HGNC: 19296
Ensembl: ENSG00000080224

Variants:

dbSNP: 285220
ClinVar: 285220
TCGA: ENSG00000080224
COSMIC: EPHA6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000080224ENST00000389672A0A0B4J1T8
ENSG00000080224ENST00000470610E7EU71
ENSG00000080224ENST00000477384J3KR66
ENSG00000080224ENST00000502694Q9UF33
ENSG00000080224ENST00000503760B4DXM2
ENSG00000080224ENST00000506349H0Y8K5
ENSG00000080224ENST00000506569H0Y9V0
ENSG00000080224ENST00000508345B4DXQ6
ENSG00000080224ENST00000514100Q9UF33

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
EPH-Ephrin signalingREACTOMER-HSA-2682334
EPHA-mediated growth cone collapseREACTOMER-HSA-3928663
EPH-ephrin mediated repulsion of cellsREACTOMER-HSA-3928665

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
314839182019Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis.9
314839182019Tyrosine kinase Eph receptor A6 sensitizes glioma-initiating cells towards bone morphogenetic protein-induced apoptosis.9
275824842017Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.9
292080022017EPHA6 rs4857055 C > T polymorphism associates with hypertension through triglyceride and LDL particle size in the Korean population.3
275824842017Targeted Sequencing Reveals Low-Frequency Variants in EPHA Genes as Markers of Paclitaxel-Induced Peripheral Neuropathy.9
292080022017EPHA6 rs4857055 C > T polymorphism associates with hypertension through triglyceride and LDL particle size in the Korean population.3
255834932015Novel recurrently mutated genes in African American colon cancers.78
260418872015EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression.26
255834932015Novel recurrently mutated genes in African American colon cancers.78
260418872015EphA6 promotes angiogenesis and prostate cancer metastasis and is associated with human prostate cancer progression.26
198502832010Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.34
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
209507862010A genome-wide study reveals copy number variants exclusive to childhood obesity cases.49
198502832010Identification of novel candidate genes for treatment response to risperidone and susceptibility for schizophrenia: integrated analysis among pharmacogenomics, mouse expression, and genetic case-control association approaches.34
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78

Citation

Dessen P

EPHA6 (EPH receptor A6)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43244/tumors-explorer/css/lib/gene-fusions-explorer/meetings/