GRAP (GRB2 related adaptor protein)

2006-10-01 Affiliation

Identity

HGNC

GRAP

LOCATION

17p11.2

LOCUSID

10750

ALIAS

DFNB114

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 10750
MIM: 604330
HGNC: 4562
Ensembl: ENSG00000154016

Variants:

dbSNP: 10750
ClinVar: 10750
TCGA: ENSG00000154016
COSMIC: GRAP

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000154016	ENST00000284154	Q13588
ENSG00000154016	ENST00000395635	A8MW78
ENSG00000154016	ENST00000573099	I3L2P9
ENSG00000154016	ENST00000583020	J3QRP9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by SCF-KIT	REACTOME	R-HSA-1433557

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
35972996	2022	m(6)A Modification-mediated GRAP Regulates Vascular Remodeling in Hypoxic Pulmonary Hypertension.	6
35972996	2022	m(6)A Modification-mediated GRAP Regulates Vascular Remodeling in Hypoxic Pulmonary Hypertension.	6
30610177	2019	Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss.	6
30610177	2019	Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss.	6
29364705	2018	miR-654-5p Targets GRAP to Promote Proliferation, Metastasis, and Chemoresistance of Oral Squamous Cell Carcinoma Through Ras/MAPK Signaling.	39
29364705	2018	miR-654-5p Targets GRAP to Promote Proliferation, Metastasis, and Chemoresistance of Oral Squamous Cell Carcinoma Through Ras/MAPK Signaling.	39
19836472	2010	Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.	14
19836472	2010	Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.	14
18295596	2008	CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.	8
18295596	2008	CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.	8
15174222	2004	Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.	1
15174222	2004	Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.	1
12491092	2003	Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity.	9
12491092	2003	Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity.	9

Citation

Dessen P

GRAP (GRB2 related adaptor protein)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43299/favicon/js/lib/humanGenome