GRAP (GRB2 related adaptor protein)

2006-10-01  

Identity

HGNC
LOCATION
17p11.2
LOCUSID
ALIAS
DFNB114
FUSION GENES

Other Information

Locus ID:

NCBI: 10750
MIM: 604330
HGNC: 4562
Ensembl: ENSG00000154016

Variants:

dbSNP: 10750
ClinVar: 10750
TCGA: ENSG00000154016
COSMIC: GRAP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000154016ENST00000284154Q13588
ENSG00000154016ENST00000395635A8MW78
ENSG00000154016ENST00000573099I3L2P9
ENSG00000154016ENST00000583020J3QRP9

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by SCF-KITREACTOMER-HSA-1433557

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
359729962022m(6)A Modification-mediated GRAP Regulates Vascular Remodeling in Hypoxic Pulmonary Hypertension.6
359729962022m(6)A Modification-mediated GRAP Regulates Vascular Remodeling in Hypoxic Pulmonary Hypertension.6
306101772019Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss.6
306101772019Dysfunction of GRAP, encoding the GRB2-related adaptor protein, is linked to sensorineural hearing loss.6
293647052018miR-654-5p Targets GRAP to Promote Proliferation, Metastasis, and Chemoresistance of Oral Squamous Cell Carcinoma Through Ras/MAPK Signaling.39
293647052018miR-654-5p Targets GRAP to Promote Proliferation, Metastasis, and Chemoresistance of Oral Squamous Cell Carcinoma Through Ras/MAPK Signaling.39
198364722010Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.14
198364722010Quantitative mass spectrometry of diabetic kidney tubules identifies GRAP as a novel regulator of TGF-beta signaling.14
182955962008CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.8
182955962008CD28 and Grb-2, relative to Gads or Grap, preferentially co-operate with Vav1 in the activation of NFAT/AP-1 transcription.8
151742222004Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.1
151742222004Detection of Grb-2-related adaptor protein gene (GRAP) and peptide molecule in salivary glands of MRL/lpr mice and patients with Sjögren's syndrome.1
124910922003Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity.9
124910922003Polymorphisms of four bone mineral density candidate genes in Chinese populations and comparison with other populations of different ethnicity.9

Citation

Dessen P

GRAP (GRB2 related adaptor protein)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43299/js/lib/favicon/humanGenome