INPP5A (inositol polyphosphate-5-phosphatase A)

2006-10-01  

Identity

HGNC
LOCATION
10q26.3
LOCUSID
ALIAS
5PTASE
FUSION GENES

Other Information

Locus ID:

NCBI: 3632
MIM: 600106
HGNC: 6076
Ensembl: ENSG00000068383

Variants:

dbSNP: 3632
ClinVar: 3632
TCGA: ENSG00000068383
COSMIC: INPP5A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000068383ENST00000342652H0Y2W5
ENSG00000068383ENST00000368593Q5T1B5
ENSG00000068383ENST00000368594Q14642
ENSG00000068383ENST00000423490Q5T1B3
ENSG00000068383ENST00000445580B1AP38

Expression (GTEx)

0
50
100
150

Pathways

PathwaySourceExternal ID
Inositol phosphate metabolismKEGGko00562
Phosphatidylinositol signaling systemKEGGko04070
Inositol phosphate metabolismKEGGhsa00562
Phosphatidylinositol signaling systemKEGGhsa04070
Metabolic pathwaysKEGGhsa01100
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositolKEGGhsa_M00131
Inositol phosphate metabolism, Ins(1,3,4,5)P4 => Ins(1,3,4)P3 => myo-inositolKEGGM00131
MetabolismREACTOMER-HSA-1430728
Inositol phosphate metabolismREACTOMER-HSA-1483249
Synthesis of IP2, IP, and Ins in the cytosolREACTOMER-HSA-1855183

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
286536062018miR-181a-5p Promotes Proliferation and Invasion and Inhibits Apoptosis of Cervical Cancer Cells via Regulating Inositol Polyphosphate-5-Phosphatase A (INPP5A).34
286536062018miR-181a-5p Promotes Proliferation and Invasion and Inhibits Apoptosis of Cervical Cancer Cells via Regulating Inositol Polyphosphate-5-Phosphatase A (INPP5A).34
260519442015Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice.16
260519442015Deletion of Inpp5a causes ataxia and cerebellar degeneration in mice.16
208767292010Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma.20
208767292010Loss of inositol polyphosphate 5-phosphatase is an early event in development of cutaneous squamous cell carcinoma.20

Citation

Dessen P

INPP5A (inositol polyphosphate-5-phosphatase A)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43321/favicon/css/case-report-explorer/