MCM10 (minichromosome maintenance 10 replication initiation factor)

2006-10-01  

Identity

HGNC
MCM10
LOCATION
10p13
LOCUSID
55388
ALIAS
CNA43,DNA43,IMD80,PRO2249
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55388
MIM: 609357
HGNC: 18043
Ensembl: ENSG00000065328

Variants:

dbSNP: 55388
ClinVar: 55388
TCGA: ENSG00000065328
COSMIC: MCM10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000065328ENST00000378694Q5T670
ENSG00000065328ENST00000378714Q7L590
ENSG00000065328ENST00000479669C9J600
ENSG00000065328ENST00000484800Q7L590

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell CycleREACTOMER-HSA-1640170
Cell Cycle CheckpointsREACTOMER-HSA-69620
G2/M CheckpointsREACTOMER-HSA-69481
Activation of ATR in response to replication stressREACTOMER-HSA-176187
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G1-G1/S phasesREACTOMER-HSA-453279
G1/S TransitionREACTOMER-HSA-69206
Activation of the pre-replicative complexREACTOMER-HSA-68962
Regulation of DNA replicationREACTOMER-HSA-69304
Removal of licensing factors from originsREACTOMER-HSA-69300
M/G1 TransitionREACTOMER-HSA-68874
DNA Replication Pre-InitiationREACTOMER-HSA-69002
DNA ReplicationREACTOMER-HSA-69306

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382626032024A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells.1
382626032024A critical threshold of MCM10 is required to maintain genome stability during differentiation of induced pluripotent stem cells into natural killer cells.1
378485342023MCM10, a potential diagnostic, immunological, and prognostic biomarker in pan-cancer.0
378485342023MCM10, a potential diagnostic, immunological, and prognostic biomarker in pan-cancer.0
353940242022Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation.5
358134832022Over-Activation of Minichromosome Maintenance Protein 10 Promotes Genomic Instability in Early Stages of Breast Cancer.2
353940242022Comprehensive analysis of DNA replication timing across 184 cell lines suggests a role for MCM10 in replication timing regulation.5
358134832022Over-Activation of Minichromosome Maintenance Protein 10 Promotes Genomic Instability in Early Stages of Breast Cancer.2
333404282021MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells.17
337126162021Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening.17
341854292021Aberrant MCM10 SUMOylation induces genomic instability mediated by a genetic variant associated with survival of esophageal squamous cell carcinoma.7
343507812021Prognostic significance and function of MCM10 in human hepatocellular carcinoma.5
346458152021BRCA2 associates with MCM10 to suppress PRIMPOL-mediated repriming and single-stranded gap formation after DNA damage.31
333404282021MCM10 compensates for Myc-induced DNA replication stress in breast cancer stem-like cells.17
337126162021Bi-allelic MCM10 variants associated with immune dysfunction and cardiomyopathy cause telomere shortening.17

Citation

Dessen P

MCM10 (minichromosome maintenance 10 replication initiation factor)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43357/gene-explorer/gene-fusions-explorer/tumors-explorer/