NEK10 (NIMA related kinase 10)

2006-10-01  

Identity

HGNC
NEK10
LOCATION
3p24.1
LOCUSID
152110
ALIAS
CILD44
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 152110
MIM: 618726
HGNC: 18592
Ensembl: ENSG00000163491

Variants:

dbSNP: 152110
ClinVar: 152110
TCGA: ENSG00000163491
COSMIC: NEK10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163491ENST00000295720Q6ZWH5
ENSG00000163491ENST00000341435Q6ZWH5
ENSG00000163491ENST00000383770A0A0A0MRY8
ENSG00000163491ENST00000383771Q6ZWH5
ENSG00000163491ENST00000424275H7C000
ENSG00000163491ENST00000429845Q6ZWH5
ENSG00000163491ENST00000435584H7C3L8
ENSG00000163491ENST00000435750C9JJN0

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
386839792024β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.0
386839792024β-catenin turnover is regulated by Nek10-mediated tyrosine phosphorylation in A549 lung adenocarcinoma cells.0
319599912020A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.27
324143602020Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report.12
325618512020NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity.11
319599912020A human ciliopathy reveals essential functions for NEK10 in airway mucociliary clearance.27
324143602020Homozygous truncating NEK10 mutation, associated with primary ciliary dyskinesia: a case report.12
325618512020NEK10 tyrosine phosphorylates p53 and controls its transcriptional activity.11
209565602011Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation.42
209565602011Nek10 mediates G2/M cell cycle arrest and MEK autoactivation in response to UV irradiation.42
200958542010Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.23
201451382010Common genetic variants associated with breast cancer and mammographic density measures that predict disease.29
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
200958542010Novel breast cancer risk alleles and interaction with ionizing radiation among U.S. radiologic technologists.23
201451382010Common genetic variants associated with breast cancer and mammographic density measures that predict disease.29

Citation

Dessen P

NEK10 (NIMA related kinase 10)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43370/gene-explorer/