NLK (nemo like kinase)

2006-10-01  

Identity

HGNC
NLK
LOCATION
17q11.2
LOCUSID
51701
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 51701
MIM: 609476
HGNC: 29858
Ensembl: ENSG00000087095

Variants:

dbSNP: 51701
ClinVar: 51701
TCGA: ENSG00000087095
COSMIC: NLK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000087095ENST00000407008Q9UBE8
ENSG00000087095ENST00000407008A0A024QZ12
ENSG00000087095ENST00000496808H0YD75
ENSG00000087095ENST00000582037J3QSE9

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MAPK signaling pathwayKEGGko04010
Wnt signaling pathwayKEGGko04310
Adherens junctionKEGGko04520
MAPK signaling pathwayKEGGhsa04010
Wnt signaling pathwayKEGGhsa04310
Adherens junctionKEGGhsa04520
FoxO signaling pathwayKEGGhsa04068
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
Ca2+ pathwayREACTOMER-HSA-4086398

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
373844092023Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration.3
373844092023Reduction of nemo-like kinase increases lysosome biogenesis and ameliorates TDP-43-related neurodegeneration.3
318285822020Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers.5
322365802020NLK interacts with 14‑3‑3ζ to restore the expression of E‑cadherin.3
326207512020Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.9
318285822020Somatic Mutations and Intratumoral Heterogeneity of Cancer-Related Genes NLK, YY1 and PA2G4 in Gastric and Colorectal Cancers.5
322365802020NLK interacts with 14‑3‑3ζ to restore the expression of E‑cadherin.3
326207512020Diamond Blackfan anemia is mediated by hyperactive Nemo-like kinase.9
304511122019Overexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of Lung Cancer Cells and Indicates Poor Prognosis.6
313222292019Knockdown of Nemo‑like kinase promotes metastasis in non‑small‑cell lung cancer.4
313247872019Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.25
313641242019Effect of NLK on the proliferation and invasion of laryngeal carcinoma cells by regulating CDCP1.6
304511122019Overexpression of Nemo-like Kinase Promotes the Proliferation and Invasion of Lung Cancer Cells and Indicates Poor Prognosis.6
313222292019Knockdown of Nemo‑like kinase promotes metastasis in non‑small‑cell lung cancer.4
313247872019Phosphorylation of MAVS/VISA by Nemo-like kinase (NLK) for degradation regulates the antiviral innate immune response.25

Citation

Dessen P

NLK (nemo like kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43380/css/lib/gene-fusions/meetings/