RAPGEF3 (Rap guanine nucleotide exchange factor 3)

2006-10-01  

Identity

HGNC
RAPGEF3
LOCATION
12q13.11
LOCUSID
10411
ALIAS
CAMP-GEFI,EPAC,EPAC1,HSU79275,bcm910
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10411
MIM: 606057
HGNC: 16629
Ensembl: ENSG00000079337

Variants:

dbSNP: 10411
ClinVar: 10411
TCGA: ENSG00000079337
COSMIC: RAPGEF3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000079337ENST00000389212O95398
ENSG00000079337ENST00000395358O95398
ENSG00000079337ENST00000405493O95398
ENSG00000079337ENST00000449771O95398
ENSG00000079337ENST00000466322F8W0N0
ENSG00000079337ENST00000495465H0YIP6
ENSG00000079337ENST00000495953F8VXK1
ENSG00000079337ENST00000547856F8VVJ6
ENSG00000079337ENST00000548434H0YHS2
ENSG00000079337ENST00000548919F8VRX1
ENSG00000079337ENST00000549151O95398

Expression (GTEx)

0
10
20
30
40
50
60
70
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Leukocyte transendothelial migrationKEGGko04670
Long-term potentiationKEGGko04720
Leukocyte transendothelial migrationKEGGhsa04670
Long-term potentiationKEGGhsa04720
Serotonergic synapseKEGGhsa04726
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Adrenergic signaling in cardiomyocytesKEGGhsa04261
Adrenergic signaling in cardiomyocytesKEGGko04261
cAMP signaling pathwayKEGGhsa04024
cAMP signaling pathwayKEGGko04024
Immune SystemREACTOMER-HSA-168256
Adaptive Immune SystemREACTOMER-HSA-1280218
Rap1 signallingREACTOMER-HSA-392517
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Platelet Aggregation (Plug Formation)REACTOMER-HSA-76009
Integrin alphaIIb beta3 signalingREACTOMER-HSA-354192
Signal TransductionREACTOMER-HSA-162582
MetabolismREACTOMER-HSA-1430728
Integration of energy metabolismREACTOMER-HSA-163685
Regulation of insulin secretionREACTOMER-HSA-422356
Glucagon-like Peptide-1 (GLP1) regulates insulin secretionREACTOMER-HSA-381676
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
381957072024EPAC1 enhances brown fat growth and beige adipogenesis.1
389634222024Protein SUMOylation promotes cAMP-independent EPAC1 activation.0
381957072024EPAC1 enhances brown fat growth and beige adipogenesis.1
389634222024Protein SUMOylation promotes cAMP-independent EPAC1 activation.0
376842242023Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription.1
376842242023Cyclic AMP induces reversible EPAC1 condensates that regulate histone transcription.1
358346162022EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression.2
358925922022Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids.2
358346162022EPAC Regulates Melanoma Growth by Stimulating mTORC1 Signaling and Loss of EPAC Signaling Dependence Correlates with Melanoma Progression.2
358925922022Absence of EPAC1 Signaling to Stabilize CFTR in Intestinal Organoids.2
323338212021MRP4/ABCC4 expression is regulated by histamine in acute myeloid leukemia cells, determining cAMP efflux.3
328908662021Downregulation of Epac Reduces Fibrosis and Induces Apoptosis Through Akt Signaling in Human Keloid Fibroblasts.2
332982482021Epac: new emerging cAMP-binding protein.15
334668002021GRKs and Epac1 Interaction in Cardiac Remodeling and Heart Failure.4
345719552021Identification and Characterization of an Affimer Affinity Reagent for the Detection of the cAMP Sensor, EPAC1.1

Citation

Dessen P

RAPGEF3 (Rap guanine nucleotide exchange factor 3)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43445/haematological-explorer/gene-explorer/humanGenome