DSTYK (dual serine/threonine and tyrosine protein kinase)

2006-10-01  

Identity

HGNC
LOCATION
1q32.1
LOCUSID
ALIAS
CAKUT1,DustyPK,HDCMD38P,RIP5,RIPK5,SPG23
FUSION GENES

Other Information

Locus ID:

NCBI: 25778
MIM: 612666
HGNC: 29043
Ensembl: ENSG00000133059

Variants:

dbSNP: 25778
ClinVar: 25778
TCGA: ENSG00000133059
COSMIC: DSTYK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000133059ENST00000367161Q6XUX3
ENSG00000133059ENST00000367162Q6XUX3
ENSG00000133059ENST00000615388Q6XUX3

Expression (GTEx)

0
5
10
15
20
25
30
35

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
377468492023Mouse and human studies support DSTYK loss of function as a low-penetrance and variable expressivity risk factor for congenital urinary tract anomalies.0
377468492023Mouse and human studies support DSTYK loss of function as a low-penetrance and variable expressivity risk factor for congenital urinary tract anomalies.0
361696522022DSTYK inhibition increases the sensitivity of lung cancer cells to T cell-mediated cytotoxicity.3
365551812022Aberrations in FGFR1, FGFR2, and RIP5 Expression in Human Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).5
361696522022DSTYK inhibition increases the sensitivity of lung cancer cells to T cell-mediated cytotoxicity.3
365551812022Aberrations in FGFR1, FGFR2, and RIP5 Expression in Human Congenital Anomalies of the Kidney and Urinary Tract (CAKUT).5
350116592021DSTYK Enhances Chemoresistance in Triple-Negative Breast Cancer Cells.3
350116592021DSTYK Enhances Chemoresistance in Triple-Negative Breast Cancer Cells.3
281575402017Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23.16
292380452017RIPK3 promotes adenovirus type 5 activity.11
281575402017Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23.16
292380452017RIPK3 promotes adenovirus type 5 activity.11
238629742013Mutations in DSTYK and dominant urinary tract malformations.61
238629742013Mutations in DSTYK and dominant urinary tract malformations.61
171236482006Dusty protein kinases: primary structure, gene evolution, tissue specific expression and unique features of the catalytic domain.11

Citation

Dessen P

DSTYK (dual serine/threonine and tyrosine protein kinase)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43472/case-report-explorer/haematological-explorer/