ROR1 (receptor tyrosine kinase like orphan receptor 1)

2006-10-01  

Identity

HGNC
ROR1
LOCATION
1p31.3
LOCUSID
4919
ALIAS
NTRKR1,dJ537F10.1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 4919
MIM: 602336
HGNC: 10256
Ensembl: ENSG00000185483

Variants:

dbSNP: 4919
ClinVar: 4919
TCGA: ENSG00000185483
COSMIC: ROR1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185483ENST00000371079Q01973
ENSG00000185483ENST00000371080Q01973
ENSG00000185483ENST00000545203A0A0A0MTJ5

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
Beta-catenin independent WNT signalingREACTOMER-HSA-3858494
PCP/CE pathwayREACTOMER-HSA-4086400
WNT5A-dependent internalization of FZD2, FZD5 and ROR2REACTOMER-HSA-5140745

References

Pubmed IDYearTitleCitations
382736492024ROR1 expression in mature B lymphoid neoplasms by flow cytometry.0
385316602024Role of Wnt5b-Ror1 signaling in the proliferation of pancreatic ductal adenocarcinoma cells.0
385875782024Role of the Ror family receptors in Wnt5a signaling.1
382736492024ROR1 expression in mature B lymphoid neoplasms by flow cytometry.0
385316602024Role of Wnt5b-Ror1 signaling in the proliferation of pancreatic ductal adenocarcinoma cells.0
385875782024Role of the Ror family receptors in Wnt5a signaling.1
363140762023Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells.2
367085732023MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression.0
369490682023IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.3
373011252023The onco-embryonic antigen ROR1 is a target of chimeric antigen T cells for colorectal cancer.1
373433692023ROR1/STAT3 positive feedback loop facilitates cartilage degeneration in Osteoarthritis through activation of NF-κB signaling pathway.0
374818552023Evaluation of the prognostic significance of receptor tyrosine kinase-like orphan receptor 1 (ROR1) in lung carcinoma and its relation to lymphangiogenesis and epithelial mesenchymal transition.0
363140762023Ror1 is expressed inducibly by Notch and hypoxia signaling and regulates stem cell-like property of glioblastoma cells.2
367085732023MIR-379-5p Expression in Endometrial Cancer and Its Correlation with ROR1 Expression.0
369490682023IGFBP5 is an ROR1 ligand promoting glioblastoma invasion via ROR1/HER2-CREB signaling axis.3

Citation

Dessen P

ROR1 (receptor tyrosine kinase like orphan receptor 1)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43475/haematological-explorer/css/deep-insight-explorer/cancer-prone-explorer/