STK25 (serine/threonine kinase 25)

2006-10-01  

Identity

HGNC
STK25
LOCATION
2q37.3
LOCUSID
10494
ALIAS
SOK1,YSK1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 10494
MIM: 602255
HGNC: 11404
Ensembl: ENSG00000115694

Variants:

dbSNP: 10494
ClinVar: 10494
TCGA: ENSG00000115694
COSMIC: STK25

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115694ENST00000316586O00506
ENSG00000115694ENST00000316586A0A024R4B2
ENSG00000115694ENST00000401869O00506
ENSG00000115694ENST00000401869A0A024R4B2
ENSG00000115694ENST00000403346O00506
ENSG00000115694ENST00000403346A0A024R4B2
ENSG00000115694ENST00000405585O00506
ENSG00000115694ENST00000405585A0A0S2Z4Y2
ENSG00000115694ENST00000405883O00506
ENSG00000115694ENST00000405883A0A0S2Z4Y2
ENSG00000115694ENST00000413760C9JDH9
ENSG00000115694ENST00000420551C9JFA1
ENSG00000115694ENST00000423004H7C279
ENSG00000115694ENST00000424537C9J6L2
ENSG00000115694ENST00000426941C9JN58
ENSG00000115694ENST00000429279C9JJV0
ENSG00000115694ENST00000435225C9K0M6
ENSG00000115694ENST00000436402E7EM58
ENSG00000115694ENST00000439101C9J8E8
ENSG00000115694ENST00000440109C9JIH8
ENSG00000115694ENST00000442307C9JCC0
ENSG00000115694ENST00000450497C9J232
ENSG00000115694ENST00000535007O00506
ENSG00000115694ENST00000543554O00506

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
367289892023STK25: a viable therapeutic target for cancer treatments?0
367289892023STK25: a viable therapeutic target for cancer treatments?0
346245272022Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways.7
352173612022Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.5
353491792022Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer.3
359775122022STK25 inhibits PKA signaling by phosphorylating PRKAR1A.2
346245272022Antagonizing STK25 Signaling Suppresses the Development of Hepatocellular Carcinoma Through Targeting Metabolic, Inflammatory, and Pro-Oncogenic Pathways.7
352173612022Loss of serine/threonine protein kinase 25 in retinal ganglion cells ameliorates high glucose-elicited damage through regulation of the AKT-GSK-3β/Nrf2 pathway.5
353491792022Downregulation of STK25 promotes autophagy via the Janus kinase 2/signal transducer and activator of transcription 3 pathway in colorectal cancer.3
359775122022STK25 inhibits PKA signaling by phosphorylating PRKAR1A.2
322921652020STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism.26
331708072020Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.11
322921652020STK25 suppresses Hippo signaling by regulating SAV1-STRIPAK antagonism.26
331708072020Depletion of protein kinase STK25 ameliorates renal lipotoxicity and protects against diabetic kidney disease.11
306465382019p21(WAF1/Cip1) Regulation by hYSK1 Activates SP-1 Transcription Factor and Increases MMP-2 Expression under Hypoxic Conditions.0

Citation

Dessen P

STK25 (serine/threonine kinase 25)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43510/stk25