TNKS2 (tankyrase 2)

2006-10-01  

Identity

HGNC
TNKS2
LOCATION
10q23.32
LOCUSID
80351
ALIAS
ARTD6,PARP-5b,PARP-5c,PARP5B,PARP5C,TANK2,TNKL,pART6
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 80351
MIM: 607128
HGNC: 15677
Ensembl: ENSG00000107854

Variants:

dbSNP: 80351
ClinVar: 80351
TCGA: ENSG00000107854
COSMIC: TNKS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000107854ENST00000371627Q9H2K2

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
DiseaseREACTOMER-HSA-1643685
Diseases of signal transductionREACTOMER-HSA-5663202
Signaling by WNT in cancerREACTOMER-HSA-4791275
XAV939 inhibits tankyrase, stabilizing AXINREACTOMER-HSA-5545619
Signal TransductionREACTOMER-HSA-162582
Signaling by WntREACTOMER-HSA-195721
TCF dependent signaling in response to WNTREACTOMER-HSA-201681
Degradation of AXINREACTOMER-HSA-4641257
DeubiquitinationREACTOMER-HSA-5688426
Ub-specific processing proteasesREACTOMER-HSA-5689880

References

Pubmed IDYearTitleCitations
343575072022miR-582-5p inhibits migration and chemo-resistant capabilities of colorectal cancer cells by targeting TNKS2.1
347102502022PARP5B is required for nonhomologous end joining during tumorigenesis in vivo.2
348617982022Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis.7
357332602022Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.12
343575072022miR-582-5p inhibits migration and chemo-resistant capabilities of colorectal cancer cells by targeting TNKS2.1
347102502022PARP5B is required for nonhomologous end joining during tumorigenesis in vivo.2
348617982022Down-regulation of hsa_circ_0045474 induces macrophage autophagy in tuberculosis via miR-582-5p/TNKS2 axis.7
357332602022Tankyrases inhibit innate antiviral response by PARylating VISA/MAVS and priming it for RNF146-mediated ubiquitination and degradation.12
330998472021MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.10
333611072021Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.18
338495542021MicroRNA-490-3p inhibits migration and chemoresistance of colorectal cancer cells via targeting TNKS2.6
339234432021Arpin Regulates Migration Persistence by Interacting with Both Tankyrases and the Arp2/3 Complex.5
341121122021Mapping methylation quantitative trait loci in cardiac tissues nominates risk loci and biological pathways in congenital heart disease.5
330998472021MicroRNA-206 inhibits influenza A virus replication by targeting tankyrase 2.10
333611072021Dissecting the molecular determinants of clinical PARP1 inhibitor selectivity for tankyrase1.18

Citation

Dessen P

TNKS2 (tankyrase 2)

Atlas Genet Cytogenet Oncol Haematol. 2006-10-01

Online version: http://atlasgeneticsoncology.org/gene/43535/meetings/cancer-prone-explorer/tumors-explorer/