MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3)

2007-02-01 Affiliation

Identity

HGNC

MAGI3

LOCATION

1p13.2

LOCUSID

260425

ALIAS

MAGI-3,dJ730K3.2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 260425
MIM: 615943
HGNC: 29647
Ensembl: ENSG00000081026

Variants:

dbSNP: 260425
ClinVar: 260425
TCGA: ENSG00000081026
COSMIC: MAGI3

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000081026	ENST00000307546	Q5TCQ9
ENSG00000081026	ENST00000369611	Q5TCQ9
ENSG00000081026	ENST00000369615	Q5TCQ9
ENSG00000081026	ENST00000369617	Q5TCQ9

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Rap1 signaling pathway	KEGG	hsa04015
Rap1 signaling pathway	KEGG	ko04015

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
34510826	2021	Reduced MAGI3 level by HPV18E6 contributes to Wnt/β-catenin signaling activation and cervical cancer progression.	4
34510826	2021	Reduced MAGI3 level by HPV18E6 contributes to Wnt/β-catenin signaling activation and cervical cancer progression.	4
32080912	2020	Integrated analyses identify miR-34c-3p/MAGI3 axis for the Warburg metabolism in hepatocellular carcinoma.	8
32080912	2020	Integrated analyses identify miR-34c-3p/MAGI3 axis for the Warburg metabolism in hepatocellular carcinoma.	8
29362392	2018	Premature polyadenylation of MAGI3 is associated with diminished N(6)-methyladenosine in its large internal exon.	15
29362392	2018	Premature polyadenylation of MAGI3 is associated with diminished N(6)-methyladenosine in its large internal exon.	15
28545409	2017	Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease.	13
28545409	2017	Genetic variation and expression levels of tight junction genes identifies association between MAGI3 and inflammatory bowel disease.	13
27205883	2016	Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer.	15
27205883	2016	Premature polyadenylation of MAGI3 produces a dominantly-acting oncogene in human breast cancer.	15
26248734	2015	MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression.	13
26452219	2015	MAGI3 negatively regulates Wnt/β-catenin signaling and suppresses malignant phenotypes of glioma cells.	24
26248734	2015	MAGI3 Suppresses Glioma Cell Proliferation via Upregulation of PTEN Expression.	13
26452219	2015	MAGI3 negatively regulates Wnt/β-catenin signaling and suppresses malignant phenotypes of glioma cells.	24
21134377	2011	MAGI-3 competes with NHERF-2 to negatively regulate LPA2 receptor signaling in colon cancer cells.	35

Citation

Dessen P

MAGI3 (membrane associated guanylate kinase, WW and PDZ domain containing 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43638/gene-explorer/js/lib/cancer-prone-explorer/