PGA3 (pepsinogen A3)

2007-02-01  

Identity

HGNC
PGA3
LOCATION
11q12.2
LOCUSID
643834
ALIAS
-
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 643834
MIM: 169710
HGNC: 8885
Ensembl: ENSG00000229859

Variants:

dbSNP: 643834
ClinVar: 643834
TCGA: ENSG00000229859
COSMIC: PGA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000229859ENST00000325558P0DJD8
ENSG00000229859ENST00000538258F5H0H6
ENSG00000229859ENST00000543125F5GXL4
ENSG00000229859ENST00000543505F5H842

Expression (GTEx)

0
500
1000
1500
2000
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Protein digestion and absorptionKEGGko04974
Protein digestion and absorptionKEGGhsa04974
Metabolism of proteinsREACTOMER-HSA-392499
Surfactant metabolismREACTOMER-HSA-5683826

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
348173332021Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer.2
348173332021Diagnostic value of MRI-DWI signal intensity value combined with serum PGI, PGII and CA199 in early gastric cancer.2
314145872019Significance of Serological Gastric Biopsy in Different Gastric Mucosal Lesions: an Observational Study.7
314145872019Significance of Serological Gastric Biopsy in Different Gastric Mucosal Lesions: an Observational Study.7
248951492015Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study.23
248951492015Temporal changes in serum biomarkers and risk for progression of gastric precancerous lesions: a longitudinal study.23
252920402014Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti- CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran.3
252920402014Screening of precancerous gastric lesions by serum pepsinogen, gastrin-17, anti-helicobacter pylori and anti- CagA antibodies in dyspeptic patients over 50 years old in Guilan Province, north of Iran.3
238862092013Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions.11
238862092013Serum gastrin and the pepsinogen I/II ratio as markers for diagnosis of premalignant gastric lesions.11
211757992011Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study.10
211757992011Correlation of serum pepsinogens and gastrin-17 with atrophic gastritis in gastroesophageal reflux patients: a matched-pairs study.10
188442222009Serum pepsinogens and risk of esophageal squamous dysplasia.20
191963982009Barrett's esophagus is characterized by the absence of Helicobacter pylori infection and high levels of serum pepsinogen I concentration in Japan.6
188442222009Serum pepsinogens and risk of esophageal squamous dysplasia.20

Citation

Dessen P

PGA3 (pepsinogen A3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43715/gene-explorer/