HCFC1 (host cell factor C1)

2007-02-01  

Identity

HGNC
HCFC1
LOCATION
Xq28
LOCUSID
3054
ALIAS
CFF,HCF,HCF-1,HCF1,HFC1,MRX3,PPP1R89,VCAF
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3054
MIM: 300019
HGNC: 4839
Ensembl: ENSG00000172534

Variants:

dbSNP: 3054
ClinVar: 3054
TCGA: ENSG00000172534
COSMIC: HCFC1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000172534ENST00000310441P51610
ENSG00000172534ENST00000369984A6NEM2
ENSG00000172534ENST00000444191H7C1C4

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
50
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Herpes simplex infectionKEGGko05168
Herpes simplex infectionKEGGhsa05168
Metabolism of proteinsREACTOMER-HSA-392499
Post-translational protein modificationREACTOMER-HSA-597592
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Mitochondrial biogenesisREACTOMER-HSA-1592230
Transcriptional activation of mitochondrial biogenesisREACTOMER-HSA-2151201
Chromatin organizationREACTOMER-HSA-4839726
Chromatin modifying enzymesREACTOMER-HSA-3247509
HATs acetylate histonesREACTOMER-HSA-3214847
DeubiquitinationREACTOMER-HSA-5688426
UCH proteinasesREACTOMER-HSA-5689603

References

Pubmed IDYearTitleCitations
389565802024Variants in HCFC1 and MN1 genes causing intellectual disability in two Pakistani families.0
389565802024Variants in HCFC1 and MN1 genes causing intellectual disability in two Pakistani families.0
372647432023HCFC1 variants in the proteolysis domain are associated with X-linked idiopathic partial epilepsy: Exploring the underlying mechanism.3
372647432023HCFC1 variants in the proteolysis domain are associated with X-linked idiopathic partial epilepsy: Exploring the underlying mechanism.3
335173442021Novel exon-skipping variant disrupting the basic domain of HCFC1 causes intellectual disability without metabolic abnormalities in both male and female patients.6
335173442021Novel exon-skipping variant disrupting the basic domain of HCFC1 causes intellectual disability without metabolic abnormalities in both male and female patients.6
324795992020Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2.11
330509862020MLL5, a histone modifying enzyme, regulates androgen receptor activity in prostate cancer cells by recruiting co-regulators, HCF1 and SET1.5
330976982020HCF-1 promotes cell cycle progression by regulating the expression of CDC42.2
324795992020Host cell factors stimulate HIV-1 transcription by antagonizing substrate-binding function of Siah1 ubiquitin ligase to stabilize transcription elongation factor ELL2.11
330509862020MLL5, a histone modifying enzyme, regulates androgen receptor activity in prostate cancer cells by recruiting co-regulators, HCF1 and SET1.5
330976982020HCF-1 promotes cell cycle progression by regulating the expression of CDC42.2
312272312019HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP.20
316939022019Heat-Shock Protein 90 Controls the Expression of Cell-Cycle Genes by Stabilizing Metazoan-Specific Host-Cell Factor HCFC1.11
312272312019HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP.20

Citation

Dessen P

HCFC1 (host cell factor C1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43736/img/case-report-explorer/case-report-explorer/