EIF6 (eukaryotic translation initiation factor 6)

2007-02-01  

Identity

HGNC
EIF6
LOCATION
20q11.22
LOCUSID
3692
ALIAS
CAB,EIF3A,ITGB4BP,b(2)gcn,eIF-6,p27(BBP),p27BBP
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3692
MIM: 602912
HGNC: 6159
Ensembl: ENSG00000242372

Variants:

dbSNP: 3692
ClinVar: 3692
TCGA: ENSG00000242372
COSMIC: EIF6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000242372ENST00000374436P56537
ENSG00000242372ENST00000374443P56537
ENSG00000242372ENST00000374450P56537
ENSG00000242372ENST00000415116F8WDS6
ENSG00000242372ENST00000440766F8WD20
ENSG00000242372ENST00000447927A0A0B4J1Y7
ENSG00000242372ENST00000456600B7ZBH1

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Ribosome biogenesis in eukaryotesKEGGko03008
Ribosome biogenesis in eukaryotesKEGGhsa03008

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
366512852023Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.1
377763722023Circular RNA eukaryotic translation initiation factor 6 facilitates TPC-1 cell proliferation and invasion through the microRNA-138-5p/lipase H axis.0
366512852023Dynamic states of eIF6 and SDS variants modulate interactions with uL14 of the 60S ribosomal subunit.1
377763722023Circular RNA eukaryotic translation initiation factor 6 facilitates TPC-1 cell proliferation and invasion through the microRNA-138-5p/lipase H axis.0
350247642022Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells.5
358870682022Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study.4
350247642022Eukaryotic initiation factor 6 regulates mechanical responses in endothelial cells.5
358870682022Inhibition of eIF6 Activity Reduces Hepatocellular Carcinoma Growth: An In Vivo and In Vitro Study.4
340161422021eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway.11
343854472021Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.14
344031012021Roles of HDAC2, eIF5, and eIF6 in Lung Cancer Tumorigenesis.6
344132982021Somatic genetic rescue of a germline ribosome assembly defect.26
340161422021eIF6 promotes the malignant progression of human hepatocellular carcinoma via the mTOR signaling pathway.11
343854472021Targeting of eIF6-driven translation induces a metabolic rewiring that reduces NAFLD and the consequent evolution to hepatocellular carcinoma.14
344031012021Roles of HDAC2, eIF5, and eIF6 in Lung Cancer Tumorigenesis.6

Citation

Dessen P

EIF6 (eukaryotic translation initiation factor 6)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43756/tumors-explorer/js/lib/gene-explorer/