FGFRL1 (fibroblast growth factor receptor like 1)

2007-02-01  

Identity

HGNC
FGFRL1
LOCATION
4p16.3
LOCUSID
53834
ALIAS
FGFR-5,FGFR5,FHFR

Other Information

Locus ID:

NCBI: 53834
MIM: 605830
HGNC: 3693
Ensembl: ENSG00000127418

Variants:

dbSNP: 53834
ClinVar: 53834
TCGA: ENSG00000127418
COSMIC: FGFRL1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000127418ENST00000264748Q8N441
ENSG00000127418ENST00000398484Q8N441
ENSG00000127418ENST00000504138Q8N441
ENSG00000127418ENST00000507339D6RBN8
ENSG00000127418ENST00000510644Q8N441
ENSG00000127418ENST00000512174D6REM7

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR1REACTOMER-HSA-5654736
FGFRL1 modulation of FGFR1 signalingREACTOMER-HSA-5658623

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA164924492brivanibChemicalPathwayassociated20124951
PA26880CRKGenePathwayassociated20124951
PA28115FGF2GenePathwayassociated20124951
PA33304PIK3C2AGenePathwayassociated20124951
PA33305PIK3C2BGenePathwayassociated20124951

References

Pubmed IDYearTitleCitations
370622732023Downregulation of miR-210-3p Attenuates High Glucose-Induced Angiogenesis of Vascular Endothelial Cells via Targeting FGFRL1.0
371161562023Aberrant Expression of FGFRL1 in Esophageal Cancer and Its Regulation by miR-107.0
370622732023Downregulation of miR-210-3p Attenuates High Glucose-Induced Angiogenesis of Vascular Endothelial Cells via Targeting FGFRL1.0
371161562023Aberrant Expression of FGFRL1 in Esophageal Cancer and Its Regulation by miR-107.0
359809842022FGFRL1 and FGF genes are associated with height, hypertension, and osteoporosis.4
359809842022FGFRL1 and FGF genes are associated with height, hypertension, and osteoporosis.4
334432962021Evidence that FGFRL1 contributes to congenital diaphragmatic hernia development in humans.3
334432962021Evidence that FGFRL1 contributes to congenital diaphragmatic hernia development in humans.3
319571792020FGFRL1 affects chemoresistance of small-cell lung cancer by modulating the PI3K/Akt pathway via ENO1.19
320985572020Fibroblast growth factor receptor-like-1: a new therapeutic target and unfavorable prognostic indicator for rectal adenocarcinoma.0
323962692020Lung CSC-derived exosomal miR-210-3p contributes to a pro-metastatic phenotype in lung cancer by targeting FGFRL1.36
330195322020Dissecting the Interaction of FGF8 with Receptor FGFRL1.3
330852422020[Expression of fibroblast growth factor receptor like 1 protein in oral squamous cell carcinoma and its influence on tumor cell proliferation and migration].1
319571792020FGFRL1 affects chemoresistance of small-cell lung cancer by modulating the PI3K/Akt pathway via ENO1.19
320985572020Fibroblast growth factor receptor-like-1: a new therapeutic target and unfavorable prognostic indicator for rectal adenocarcinoma.0

Citation

Dessen P

FGFRL1 (fibroblast growth factor receptor like 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43781/js/humanGenome