IFI16 (interferon gamma inducible protein 16)

2007-02-01  

Identity

HGNC
IFI16
LOCATION
1q23.1
LOCUSID
3428
ALIAS
IFNGIP1,PYHIN2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3428
MIM: 147586
HGNC: 5395
Ensembl: ENSG00000163565

Variants:

dbSNP: 3428
ClinVar: 3428
TCGA: ENSG00000163565
COSMIC: IFI16

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000163565ENST00000295809Q16666
ENSG00000163565ENST00000340979A0A0A0MRB1
ENSG00000163565ENST00000359709Q16666
ENSG00000163565ENST00000368131Q16666
ENSG00000163565ENST00000368132Q16666
ENSG00000163565ENST00000426592H3BM18
ENSG00000163565ENST00000447473X6RHM1
ENSG00000163565ENST00000448393Q16666
ENSG00000163565ENST00000474473H3BR88
ENSG00000163565ENST00000566111H3BVE6
ENSG00000163565ENST00000567661H3BR65

Expression (GTEx)

0
50
100
150
200
250
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
NOD-like receptor signaling pathwayKEGGko04621
NOD-like receptor signaling pathwayKEGGhsa04621
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Cytosolic sensors of pathogen-associated DNAREACTOMER-HSA-1834949
STING mediated induction of host immune responsesREACTOMER-HSA-1834941
IRF3-mediated induction of type I IFNREACTOMER-HSA-3270619

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
374801962024Association of salivary levels of DNA sensing inflammasomes AIM2, IFI16, and cytokine IL18 with periodontitis and diabetes.0
384669442024IFI16 Positively Regulates RIG-I-Mediated Type I Interferon Production in a STING-Independent Manner.0
385422982024IFI16 Is Indispensable for Promoting HIF-1α-Mediated APOL1 Expression in Human Podocytes under Hypoxic Conditions.0
374801962024Association of salivary levels of DNA sensing inflammasomes AIM2, IFI16, and cytokine IL18 with periodontitis and diabetes.0
384669442024IFI16 Positively Regulates RIG-I-Mediated Type I Interferon Production in a STING-Independent Manner.0
385422982024IFI16 Is Indispensable for Promoting HIF-1α-Mediated APOL1 Expression in Human Podocytes under Hypoxic Conditions.0
367490732023Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.2
368646672023Filament assembly underpins the double-stranded DNA specificity of AIM2-like receptors.3
368704252023Inflammasome genes polymorphisms are associated with progression to mechanical ventilation and death in a cohort of hospitalized COVID-19 patients in a reference hospital in Rio de Janeiro, Brazil.2
370629412023IFI16/Ifi202 released from breast cancer induces secretion of inflammatory cytokines from macrophages and promotes tumor growth.2
372830742023IFI16 phase separation via multi-phosphorylation drives innate immune signaling.7
375856492023Effects of AIM2 and IFI16 on Infectious Diseases and Inflammation.4
379983382023IFI16 Induced by Direct Interaction between Esophageal Squamous Cell Carcinomas and Macrophages Promotes Tumor Progression via Secretion of IL-1α.0
367490732023Sirt1 Negatively Regulates Cellular Antiviral Responses by Preventing the Cytoplasmic Translocation of Interferon-Inducible Protein 16 in Human Cells.2
368646672023Filament assembly underpins the double-stranded DNA specificity of AIM2-like receptors.3

Citation

Dessen P

IFI16 (interferon gamma inducible protein 16)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43784/case-report-explorer/case-report-explorer/meetings/