HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)

2007-02-01  

Identity

HGNC
HNRNPA1
LOCATION
12q13.13
LOCUSID
3178
ALIAS
ALS19,ALS20,HNRPA1,HNRPA1L3,IBMPFD3,UP
FUSION GENES
Show Gene Fusions

Article Bibliography

Pubmed IDLast YearTitleAuthors

Other Information

Locus ID:

NCBI: 3178
MIM: 164017
HGNC: 5031
Ensembl: ENSG00000135486

Variants:

dbSNP: 3178
ClinVar: 3178
TCGA: ENSG00000135486
COSMIC: HNRNPA1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000135486ENST00000330752F8W6I7
ENSG00000135486ENST00000340913P09651
ENSG00000135486ENST00000340913A0A024RAZ7
ENSG00000135486ENST00000546500P09651
ENSG00000135486ENST00000546500A0A024RB53
ENSG00000135486ENST00000547276P09651
ENSG00000135486ENST00000547566P09651
ENSG00000135486ENST00000547566A0A024RB53
ENSG00000135486ENST00000547708F8W646
ENSG00000135486ENST00000548688F8VZ49
ENSG00000135486ENST00000550482H0YH80
ENSG00000135486ENST00000550994F8VYN5
ENSG00000135486ENST00000551702F8VTQ5

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
SpliceosomeKEGGko03040
SpliceosomeKEGGhsa03040
Signal TransductionREACTOMER-HSA-162582
Signaling by FGFRREACTOMER-HSA-190236
Signaling by FGFR2REACTOMER-HSA-5654738
Gene ExpressionREACTOMER-HSA-74160
Processing of Capped Intron-Containing Pre-mRNAREACTOMER-HSA-72203
mRNA SplicingREACTOMER-HSA-72172
mRNA Splicing - Major PathwayREACTOMER-HSA-72163
FGFR2 alternative splicingREACTOMER-HSA-6803529

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
378975082024N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation.2
381824292024A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks.0
381916212024hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS).2
382680302024MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation.0
386854512024circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer.1
388671902024Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing.0
378975082024N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation.2
381824292024A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks.0
381916212024hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS).2
382680302024MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation.0
386854512024circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer.1
388671902024Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing.0
364608052023A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA.4
375259102023HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells.0
377179392023The mechanism of UP1 binding and unfolding of human telomeric DNA G-quadruplex.0

Citation

Dessen P

HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43803/css/lib/favicon/gene-fusions/?id=43803