HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)

2007-02-01 Affiliation

Identity

HGNC

HNRNPA1

LOCATION

12q13.13

LOCUSID

3178

ALIAS

ALS19,ALS20,HNRPA1,HNRPA1L3,IBMPFD3,UP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Bibliography

Pubmed ID	Last Year	Title	Authors

Other Information

Locus ID:

NCBI: 3178
MIM: 164017
HGNC: 5031
Ensembl: ENSG00000135486

Variants:

dbSNP: 3178
ClinVar: 3178
TCGA: ENSG00000135486
COSMIC: HNRNPA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135486	ENST00000330752	F8W6I7
ENSG00000135486	ENST00000340913	P09651
ENSG00000135486	ENST00000340913	A0A024RAZ7
ENSG00000135486	ENST00000546500	P09651
ENSG00000135486	ENST00000546500	A0A024RB53
ENSG00000135486	ENST00000547276	P09651
ENSG00000135486	ENST00000547566	P09651
ENSG00000135486	ENST00000547566	A0A024RB53
ENSG00000135486	ENST00000547708	F8W646
ENSG00000135486	ENST00000548688	F8VZ49
ENSG00000135486	ENST00000550482	H0YH80
ENSG00000135486	ENST00000550994	F8VYN5
ENSG00000135486	ENST00000551702	F8VTQ5

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Signal Transduction	REACTOME	R-HSA-162582
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR2	REACTOME	R-HSA-5654738
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163
FGFR2 alternative splicing	REACTOME	R-HSA-6803529

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
23455423	2013	Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.	460
20010808	2010	HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.	391
26412307	2015	Formation and Maturation of Phase-Separated Liquid Droplets by RNA-Binding Proteins.	342
17558416	2007	The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a.	232
20133837	2010	The alternative splicing repressors hnRNP A1/A2 and PTB influence pyruvate kinase isoform expression and cell metabolism.	176
11779509	2001	Exon identity established through differential antagonism between exonic splicing silencer-bound hnRNP A1 and enhancer-bound SR proteins.	150
21399625	2011	TERRA and hnRNPA1 orchestrate an RPA-to-POT1 switch on telomeric single-stranded DNA.	139
20639884	2010	Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis.	128
19913121	2009	Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.	85
19339352	2009	hnRNP A1 interacts with the 5' untranslated regions of enterovirus 71 and Sindbis virus RNA and is required for viral replication.	75

Citation

Dessen P

HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43803/css/lib/humanGenome