HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)

2007-02-01 Affiliation

Identity

HGNC

HNRNPA1

LOCATION

12q13.13

LOCUSID

3178

ALIAS

ALS19,ALS20,HNRPA1,HNRPA1L3,IBMPFD3,UP

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Article Bibliography

Pubmed ID	Last Year	Title	Authors
20716340	2010	Deregulated expression of hnRNP A/B proteins in human non-small cell lung cancer: parallel assessment of protein and mRNA levels in paired tumour/non-tumour tissues.	Boukakis G et al
17898077	2007	Cytoplasmic relocalization of heterogeneous nuclear ribonucleoprotein A1 controls translation initiation of specific mRNAs.	Cammas A et al
12799433	2003	Specific interaction of heterogeneous nuclear ribonucleoprotein A1 with the -219T allelic form modulates APOE promoter activity.	Campillos M et al
12716975	2003	Heterogeneous nuclear ribonucleoprotein (hnRNP) binding to hormone response elements: a cause of vitamin D resistance.	Chen H et al
29484423	2018	High expression of hnRNPA1 promotes cell invasion by inducing EMT in gastric cancer.	Chen Y et al
17950949	2008	The alternative splicing factor hnRNP A1 is up-regulated during virus-infected epithelial cell differentiation and binds the human papillomavirus type 16 late regulatory element.	Cheunim T et al
20010808	2010	HnRNP proteins controlled by c-Myc deregulate pyruvate kinase mRNA splicing in cancer.	David CJ et al
3072706	1988	Heterogeneous nuclear ribonucleoprotein particles and the pathway of mRNA formation.	Dreyfuss G et al
24166503	2014	microRNA-18a induces apoptosis in colon cancer cells via the autophagolysosomal degradation of oncogenic heterogeneous nuclear ribonucleoprotein A1.	Fujiya M et al
27149842	2016	Genomic Correlates of Immune-Cell Infiltrates in Colorectal Carcinoma.	Giannakis M et al
18391021	2008	Binding of DAZAP1 and hnRNPA1/A2 to an exonic splicing silencer in a natural BRCA1 exon 18 mutant.	Goina E et al
17558416	2007	The multifunctional RNA-binding protein hnRNP A1 is required for processing of miR-18a.	Guil S et al
20795951	2010	Functional diversity of the hnRNPs: past, present and perspectives.	Han SP et al
11313474	2001	Interaction between hnRNPA1 and IkappaBalpha is required for maximal activation of NF-kappaB-dependent transcription.	Hay DC et al
25338872	2015	Loss of hnRNPA1 in ALS spinal cord motor neurons with TDP-43-positive inclusions.	Honda H et al
12060656	2002	Distinct sets of adjacent heterogeneous nuclear ribonucleoprotein (hnRNP) A1/A2 binding sites control 5' splice site selection in the hnRNP A1 mRNA precursor.	Hutchison S et al
27066560	2015	Isolated inclusion body myopathy caused by a multisystem proteinopathy-linked hnRNPA1 mutation.	Izumi R et al
17289661	2007	Molecular composition of IMP1 ribonucleoprotein granules.	Jønson L et al
24065100	2013	hnRNP A1: the Swiss army knife of gene expression.	Jean-Philippe J et al
23455423	2013	Mutations in prion-like domains in hnRNPA2B1 and hnRNPA1 cause multisystem proteinopathy and ALS.	Kim HJ et al
27984373	2017	HNRNPA1, a Splicing Regulator, Is an Effective Target Protein for Cervical Cancer Detection: Comparison With Conventional Tumor Markers.	Kim YJ et al
10972977	2000	Heterogeneous nuclear ribonucleoproteins as regulators of gene expression through interactions with the human thymidine kinase promoter.	Lau JS et al
27694260	2016	Whole-exome sequencing identifies a missense mutation in hnRNPA1 in a family with flail arm ALS.	Liu Q et al
26581508	2016	Knockdown of HNRNPA1 inhibits lung adenocarcinoma cell proliferation through cell cycle arrest at G0/G1 phase.	Liu X et al
26151392	2015	CD44 alternative splicing and hnRNP A1 expression are associated with the metastasis of breast cancer.	Loh TJ et al
22536116	2012	Alternative Mechanisms to Initiate Translation in Eukaryotic mRNAs.	Martínez-Salas E et al
15448691	2004	Nonsense surveillance regulates expression of diverse classes of mammalian transcripts and mutes genomic noise.	Mendell JT et al
20639884	2010	Antagonistic role of hnRNP A1 and KSRP in the regulation of let-7a biogenesis.	Michlewski G et al
11585913	2001	Distinct RNP complexes of shuttling hnRNP proteins with pre-mRNA and mRNA: candidate intermediates in formation and export of mRNA.	Mili S et al
29872500	2018	Regulatory role of resveratrol, a microRNA-controlling compound, in HNRNPA1 expression, which is associated with poor prognosis in breast cancer.	Otsuka K et al
1371331	1992	Shuttling of pre-mRNA binding proteins between nucleus and cytoplasm.	Piñol-Roma S et al
25324306	2014	hnRNPA1 couples nuclear export and translation of specific mRNAs downstream of FGF-2/S6K2 signalling.	Roy R et al
22922191	2012	The hnRNP A1 homolog Hrp36 is essential for normal development, female fecundity, omega speckle formation and stress tolerance in Drosophila melanogaster.	Singh AK et al
22132154	2011	hnRNP A1 and hnRNP F modulate the alternative splicing of exon 11 of the insulin receptor gene.	Talukdar I et al
23052036	2013	Endocrine disruptors fludioxonil and fenhexamid stimulate miR-21 expression in breast cancer cells.	Teng Y et al
15703818	2005	Up-regulation of hnRNP A1 gene in sporadic human colorectal cancers.	Ushigome M et al
15671034	2005	Regulation of gamma-fibrinogen chain expression by heterogeneous nuclear ribonucleoprotein A1.	Xia H et al
29367466	2018	Mutations in Hnrnpa1 cause congenital heart defects.	Yu Z et al
16603717	2006	hnRNP A1 associates with telomere ends and stimulates telomerase activity.	Zhang QS et al
22821376	2013	Overexpression of HnRNP A1 promotes tumor invasion through regulating CD44v6 and indicates poor prognosis for hepatocellular carcinoma.	Zhou ZJ et al

Other Information

Locus ID:

NCBI: 3178
MIM: 164017
HGNC: 5031
Ensembl: ENSG00000135486

Variants:

dbSNP: 3178
ClinVar: 3178
TCGA: ENSG00000135486
COSMIC: HNRNPA1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000135486	ENST00000330752	F8W6I7
ENSG00000135486	ENST00000340913	P09651
ENSG00000135486	ENST00000340913	A0A024RAZ7
ENSG00000135486	ENST00000546500	P09651
ENSG00000135486	ENST00000546500	A0A024RB53
ENSG00000135486	ENST00000547276	P09651
ENSG00000135486	ENST00000547566	P09651
ENSG00000135486	ENST00000547566	A0A024RB53
ENSG00000135486	ENST00000547708	F8W646
ENSG00000135486	ENST00000548688	F8VZ49
ENSG00000135486	ENST00000550482	H0YH80
ENSG00000135486	ENST00000550994	F8VYN5
ENSG00000135486	ENST00000551702	F8VTQ5

Expression (GTEx)

500

1000

1500

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Spliceosome	KEGG	ko03040
Spliceosome	KEGG	hsa03040
Signal Transduction	REACTOME	R-HSA-162582
Signaling by FGFR	REACTOME	R-HSA-190236
Signaling by FGFR2	REACTOME	R-HSA-5654738
Gene Expression	REACTOME	R-HSA-74160
Processing of Capped Intron-Containing Pre-mRNA	REACTOME	R-HSA-72203
mRNA Splicing	REACTOME	R-HSA-72172
mRNA Splicing - Major Pathway	REACTOME	R-HSA-72163
FGFR2 alternative splicing	REACTOME	R-HSA-6803529

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
37897508	2024	N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation.	2
38182429	2024	A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks.	0
38191621	2024	hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS).	2
38268030	2024	MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation.	0
38685451	2024	circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer.	1
38867190	2024	Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing.	0
37897508	2024	N6-methyladenosine modification of OIP5-AS1 promotes glycolysis, tumorigenesis, and metastasis of gastric cancer by inhibiting Trim21-mediated hnRNPA1 ubiquitination and degradation.	2
38182429	2024	A mutation in the low-complexity domain of splicing factor hnRNPA1 linked to amyotrophic lateral sclerosis disrupts distinct neuronal RNA splicing networks.	0
38191621	2024	hnRNP A1 dysfunction alters RNA splicing and drives neurodegeneration in multiple sclerosis (MS).	2
38268030	2024	MAGOH promotes gastric cancer progression via hnRNPA1 expression inhibition-mediated RONΔ160/PI3K/AKT signaling pathway activation.	0
38685451	2024	circLIFR-007 reduces liver metastasis via promoting hnRNPA1 nuclear export and YAP phosphorylation in breast cancer.	1
38867190	2024	Downregulation of HNRNPA1 induced neoantigen generation via regulating alternative splicing.	0
36460805	2023	A comprehensive understanding of hnRNP A1 role in cancer: new perspectives on binding with noncoding RNA.	4
37525910	2023	HnRNP A1 Suppresses the Odontogenic Differentiation and the Inclusion of RUNX2 Exon 5 of Dental Mesenchymal Cells.	0
37717939	2023	The mechanism of UP1 binding and unfolding of human telomeric DNA G-quadruplex.	0

Citation

Dessen P

HNRNPA1 (heterogeneous nuclear ribonucleoprotein A1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43803/gene-fusions-explorer/case-report-explorer/teaching-explorer/