KCNA3 (potassium voltage-gated channel subfamily A member 3)

2007-02-01  

Identity

HGNC
KCNA3
LOCATION
1p13.3
LOCUSID
3738
ALIAS
HGK5,HLK3,HPCN3,HUKIII,KV1.3,MK3,PCN3

Other Information

Locus ID:

NCBI: 3738
MIM: 176263
HGNC: 6221
Ensembl: ENSG00000177272

Variants:

dbSNP: 3738
ClinVar: 3738
TCGA: ENSG00000177272
COSMIC: KCNA3

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000177272ENST00000369769P22001

Expression (GTEx)

0
1
2
3
4
5
6
7
8
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Neuronal SystemREACTOMER-HSA-112316
Potassium ChannelsREACTOMER-HSA-1296071
Voltage gated Potassium channelsREACTOMER-HSA-1296072

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379644872024De novo variants in KCNA3 cause developmental and epileptic encephalopathy.1
385427322024Effect of the rs2821557 Polymorphism of the Human Kv1.3 Gene on Olfactory Function and BMI in Different Age Groups.0
379644872024De novo variants in KCNA3 cause developmental and epileptic encephalopathy.1
385427322024Effect of the rs2821557 Polymorphism of the Human Kv1.3 Gene on Olfactory Function and BMI in Different Age Groups.0
350914712022Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.13
353287332022Role of C-Terminal Domain and Membrane Potential in the Mobility of Kv1.3 Channels in Immune Synapse Forming T Cells.0
357885862022Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.21
365010162022Olfactory Sensitivity Is Associated with Body Mass Index and Polymorphism in the Voltage-Gated Potassium Channels Kv1.3.4
350914712022Rearrangement of a unique Kv1.3 selectivity filter conformation upon binding of a drug.13
353287332022Role of C-Terminal Domain and Membrane Potential in the Mobility of Kv1.3 Channels in Immune Synapse Forming T Cells.0
357885862022Structures of the T cell potassium channel Kv1.3 with immunoglobulin modulators.21
365010162022Olfactory Sensitivity Is Associated with Body Mass Index and Polymorphism in the Voltage-Gated Potassium Channels Kv1.3.4
320562712021A common genetic variant rs2821557 in KCNA3 is linked to the severity of multiple sclerosis.3
329105092021The Kv1.3 ion channel acts as a host factor restricting viral entry.0
332308472021Voltage-dependent conformational changes of Kv1.3 channels activate cell proliferation.5

Citation

Dessen P

KCNA3 (potassium voltage-gated channel subfamily A member 3)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43811/gene-fusions-explorer/js/lib/gene-fusions-explorer/