NFATC4 (nuclear factor of activated T cells 4)

2007-02-01  

Identity

HGNC
NFATC4
LOCATION
14q12
LOCUSID
4776
ALIAS
NF-AT3,NF-ATC4,NFAT3

Other Information

Locus ID:

NCBI: 4776
MIM: 602699
HGNC: 7778
Ensembl: ENSG00000100968

Variants:

dbSNP: 4776
ClinVar: 4776
TCGA: ENSG00000100968
COSMIC: NFATC4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100968ENST00000250373Q14934
ENSG00000100968ENST00000413692Q14934
ENSG00000100968ENST00000422617Q14934
ENSG00000100968ENST00000424781Q14934
ENSG00000100968ENST00000539237Q14934
ENSG00000100968ENST00000553469Q14934
ENSG00000100968ENST00000553708Q14934
ENSG00000100968ENST00000553879Q14934
ENSG00000100968ENST00000554050Q14934
ENSG00000100968ENST00000554344Q14934
ENSG00000100968ENST00000554473Q14934
ENSG00000100968ENST00000554591Q14934
ENSG00000100968ENST00000554661Q14934
ENSG00000100968ENST00000554779G3V4U6
ENSG00000100968ENST00000554903G3V4K1
ENSG00000100968ENST00000554966Q14934
ENSG00000100968ENST00000555167Q14934
ENSG00000100968ENST00000555393Q14934
ENSG00000100968ENST00000555453Q14934
ENSG00000100968ENST00000555590Q14934
ENSG00000100968ENST00000555802Q14934
ENSG00000100968ENST00000556169Q14934
ENSG00000100968ENST00000556279Q14934
ENSG00000100968ENST00000556759Q14934
ENSG00000100968ENST00000557451Q14934
ENSG00000100968ENST00000557674G3V5H0
ENSG00000100968ENST00000557767Q14934

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Wnt signaling pathwayKEGGko04310
Axon guidanceKEGGko04360
Wnt signaling pathwayKEGGhsa04310
Axon guidanceKEGGhsa04360
HTLV-I infectionKEGGko05166
HTLV-I infectionKEGGhsa05166
Hepatitis BKEGGhsa05161
Oxytocin signaling pathwayKEGGhsa04921
Oxytocin signaling pathwayKEGGko04921
cGMP-PKG signaling pathwayKEGGhsa04022
cGMP-PKG signaling pathwayKEGGko04022

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA33678PPP3CAGenePathwayassociated23922006
PA33679PPP3CBGenePathwayassociated23922006
PA33680PPP3CCGenePathwayassociated23922006
PA33681PPP3R1GenePathwayassociated23922006
PA33682PPP3R2GenePathwayassociated23922006

References

Pubmed IDYearTitleCitations
321822162020NFATC4 promotes quiescence and chemotherapy resistance in ovarian cancer.25
328051872020NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3 Transcriptional Activity.10
321822162020NFATC4 promotes quiescence and chemotherapy resistance in ovarian cancer.25
328051872020NULP1 Alleviates Cardiac Hypertrophy by Suppressing NFAT3 Transcriptional Activity.10
291804892018Downregulation of NFAT3 Due to Lack of T-Box Transcription Factor TBX5 Is Crucial for Cytokine Expression in T Cells.9
291804892018Downregulation of NFAT3 Due to Lack of T-Box Transcription Factor TBX5 Is Crucial for Cytokine Expression in T Cells.9
278937132017Phosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer.16
287609262017Distinct roles of NFATc1 and NFATc4 in human primary myoblast differentiation and in the maintenance of reserve cells.7
278937132017Phosphorylation of NFAT3 by CDK3 induces cell transformation and promotes tumor growth in skin cancer.16
287609262017Distinct roles of NFATc1 and NFATc4 in human primary myoblast differentiation and in the maintenance of reserve cells.7
273070452016Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.17
273070452016Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway.17
265270572015NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.8
265270572015NFAT isoforms play distinct roles in TNFα-induced retinal leukostasis.8
254221382014Increased expression of NF-AT3 and NF-AT4 in the atria correlates with procollagen I carboxyl terminal peptide and TGF-β1 levels in serum of patients with atrial fibrillation.5

Citation

Dessen P

NFATC4 (nuclear factor of activated T cells 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/43963/css/lib/gene-fusions-explorer/deep-insight-explorer/