GRHPR (glyoxylate and hydroxypyruvate reductase)

2007-06-01  

Identity

HGNC
GRHPR
LOCATION
9p13.2
LOCUSID
9380
ALIAS
GLXR,GLYD,PH2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9380
MIM: 604296
HGNC: 4570
Ensembl: ENSG00000137106

Variants:

dbSNP: 9380
ClinVar: 9380
TCGA: ENSG00000137106
COSMIC: GRHPR

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137106ENST00000318158Q9UBQ7
ENSG00000137106ENST00000318158A0A384N605
ENSG00000137106ENST00000494290Q9UBQ7
ENSG00000137106ENST00000607784U3KQ56

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Glycine, serine and threonine metabolismKEGGko00260
Pyruvate metabolismKEGGko00620
Glyoxylate and dicarboxylate metabolismKEGGko00630
Glycine, serine and threonine metabolismKEGGhsa00260
Pyruvate metabolismKEGGhsa00620
Glyoxylate and dicarboxylate metabolismKEGGhsa00630
Metabolic pathwaysKEGGhsa01100
MetabolismREACTOMER-HSA-1430728
Metabolism of amino acids and derivativesREACTOMER-HSA-71291
Glyoxylate metabolism and glycine degradationREACTOMER-HSA-389661

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
382006642024Glyoxylate reductase: Definitive identification in human liver mitochondria, its importance for the compartment-specific detoxification of glyoxylate.1
382006642024Glyoxylate reductase: Definitive identification in human liver mitochondria, its importance for the compartment-specific detoxification of glyoxylate.1
342891612021Glyoxylate reductase/hydroxypyruvate reductase regulates the free d-aspartate level in mammalian cells.1
342891612021Glyoxylate reductase/hydroxypyruvate reductase regulates the free d-aspartate level in mammalian cells.1
241169212014Ethnic differences in GRHPR mutations in patients with primary hyperoxaluria type 2.2
241169212014Ethnic differences in GRHPR mutations in patients with primary hyperoxaluria type 2.2
234861612013Glyoxylate reductase/hydroxypyruvate reductase: a novel prognostic marker for hepatocellular carcinoma patients after curative resection.3
235990412013Glyoxalate reductase/hydroxypyruvate reductase interacts with the sodium-dependent vitamin C transporter-1 to regulate cellular vitamin C homeostasis.7
234861612013Glyoxylate reductase/hydroxypyruvate reductase: a novel prognostic marker for hepatocellular carcinoma patients after curative resection.3
235990412013Glyoxalate reductase/hydroxypyruvate reductase interacts with the sodium-dependent vitamin C transporter-1 to regulate cellular vitamin C homeostasis.7
192969822009Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling.1
192969822009Late diagnosis of primary hyperoxaluria type 2 in the adult: effect of a novel mutation in GRHPR gene on enzymatic activity and molecular modeling.1
175100932007A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2.1
175100932007A novel mutation in the GRHPR gene in a Japanese patient with primary hyperoxaluria type 2.1
167569932006Structural basis of substrate specificity in human glyoxylate reductase/hydroxypyruvate reductase.18

Citation

Dessen P

GRHPR (glyoxylate and hydroxypyruvate reductase)

Atlas Genet Cytogenet Oncol Haematol. 2007-06-01

Online version: http://atlasgeneticsoncology.org/gene/44026/favicon/cancer-prone-explorer/