FSCN1 (fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus))

2008-11-01   Shoichi Nagai  , Christian A Smith  , Soma Mondal  , James T Rutka  

The Arthur, Sonia Labatt Brain Tumour Research Centre, The Hospital for Sick Children, University of Toronto, Toronto, Ontario, Canada

Identity

HGNC
FSCN1
LOCATION
7p22.1
LOCUSID
6624
ALIAS
FAN1,HSN,SNL,p55
FUSION GENES
Show Gene Fusions

DNA/RNA

Atlas Image

Description

The gene encompasses 13,833 bp of DNA.

Transcription

The length of the transcript is 2,819 bp containing 1,482 bp open reading frame.

Proteins

Description

FSCN1 encodes a 493-amino acid protein fascin with a molecular mass of 55 kD. Fascin was first isolated from sea urchin egg extracts, and then identified in Drosophila and in B-lymphocytes.

Expression

Fascin is widely expressed including the brain, blood, colon, lung, breast, ovary, and testis. In the brain, fascin expression has been localized to neurons, glial cells, and endothelial cells.

Localisation

Fascin colocalizes with filopodia, membrane ruffles, lamellopodia, microspikes, focal adhesions, cytoplasm and actin stress fibers. Additionally, fascin has been shown to localize to lamellipodia and filopodia in growth cones of cultured neurons.

Function

Fascin is an actin-bundling protein that provides rigidity to filopodial bundles to efficiently push the membrane forward during cytoskeleton remodeling and cell migration.

Mutations

Germinal

unknown

Somatic

unknown

Implicated in

Entity name
Glioma
Disease
Fascin expression increases with increasing histological grade of glioma and is associated with adhesion, migration, and invasion of glioma cells.
Entity name
Cancer
Disease
High-level expression of fascin has been observed in several types of human neoplasms, such as cancer of colon, breast, lung, kidney, ovary, cervix, and esophagus. It correlates with lymph node or distant metastasis in cancers of colon, kidney, and esophagus, and plays a role as an independent marker of poor prognosis. It is also associated with increased cellular proliferation in non-small cell lung adenocarcinoma, colon carcinoma, and esophageal squamous cell carcinoma. In colon adenocarcinoma and esophageal carcinoma cells, fascin is associated with cellular motility and invasive properties.

Article Bibliography

Pubmed IDLast YearTitleAuthors
176502132007Expression of fascin in oral and oropharyngeal squamous cell carcinomas has prognostic significance - a tissue microarray study of 129 cases.Chen SF et al
110399042000C-erbB-2/ HER-2 upregulates fascin, an actin-bundling protein associated with cell motility, in human breast cancer cell lines.Grothey A et al
170296292006Prognostic significance of fascin expression in advanced colorectal cancer: an immunohistochemical study of colorectal adenomas and adenocarcinomas.Hashimoto Y et al
182833372008The role of fascin in the migration and invasiveness of malignant glioma cells.Hwang JH et al
125078912003Fascin, an actin-bundling protein, modulates colonic epithelial cell invasiveness and differentiation in vitro.Jawhari AU et al
166200522006Actin bundling protein fascin expression in ovarian neoplasms: comparison of histopathologic features of tumors obtained by the first and secondary cytoreduction surgeries.Kabukcuoglu S et al
125923672003Independent prognostic value of fascin immunoreactivity in stage I nonsmall cell lung cancer.Pelosi G et al
147564412003Expression of fascin, an actin-bundling protein, in astrocytomas of varying grades.Peraud A et al
173750482007Independent prognostic value of fascin immunoreactivity in stage III-IV colonic adenocarcinoma.Puppa G et al
163081582005Fascin expression in 90 patients with glioblastoma multiforme.Roma AA et al
161856622005Role of fascin in the proliferation and invasiveness of esophageal carcinoma cells.Xie JJ et al
165249622006Fascin is a potential biomarker for early-stage oesophageal squamous cell carcinoma.Zhang H et al
169797272006Biologic significance of fascin expression in clear cell renal cell carcinoma: systematic analysis of primary and metastatic tumor tissues using a tissue microarray technique.Zigeuner R et al

Other Information

Locus ID:

NCBI: 6624
MIM: 602689
HGNC: 11148
Ensembl: ENSG00000075618

Variants:

dbSNP: 6624
ClinVar: 6624
TCGA: ENSG00000075618
COSMIC: FSCN1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000075618ENST00000382361Q16658
ENSG00000075618ENST00000382361A0A384MEG1
ENSG00000075618ENST00000405801A0A0A0MSB2
ENSG00000075618ENST00000444748C9JFC0
ENSG00000075618ENST00000447103C9JPH9

Expression (GTEx)

0
50
100
150
200
250
300
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MicroRNAs in cancerKEGGhsa05206
MicroRNAs in cancerKEGGko05206
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-4 and 13 signalingREACTOMER-HSA-6785807

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
379810692024CircFSCN1 induces tumor progression and triggers epithelial-mesenchymal transition in bladder cancer through augmentation of MDM2-mediated p53 silencing.1
384112742024KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma.0
384493902024SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy.1
385875712024The association of FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) polymorphisms with the risk of breast cancer in Egyptian women.0
386794642024N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma.0
389644932024The FSCN1 gene rs2966447 variant is associated with increased serum fascin-1 levels and breast cancer susceptibility.0
379810692024CircFSCN1 induces tumor progression and triggers epithelial-mesenchymal transition in bladder cancer through augmentation of MDM2-mediated p53 silencing.1
384112742024KAT8/SIRT7-mediated Fascin-K41 acetylation/deacetylation regulates tumor metastasis in esophageal squamous cell carcinoma.0
384493902024SirT7-mediated transcription of fascin in hyperglycemic glomerular endothelial cells contributes to EndMT in diabetic nephropathy.1
385875712024The association of FSCN1 (rs852479, rs1640233) and HOTAIR (rs920778) polymorphisms with the risk of breast cancer in Egyptian women.0
386794642024N6-methyladenosine methylation on FSCN1 mediated by METTL14/IGF2BP3 contributes to human papillomavirus type 16-infected cervical squamous cell carcinoma.0
389644932024The FSCN1 gene rs2966447 variant is associated with increased serum fascin-1 levels and breast cancer susceptibility.0
369276592023The role and regulatory mechanism of FSCN1 in breast tumorigenesis and progression.2
369711002023FSCN1 as a new druggable target in adrenocortical carcinoma.3
371477132023SYTL2 promotes metastasis of prostate cancer cells by enhancing FSCN1-mediated pseudopodia formation and invasion.1

Citation

Shoichi Nagai ; Christian A Smith ; Soma Mondal ; James T Rutka

FSCN1 (fascin homolog 1, actin-bundling protein (Strongylocentrotus purpuratus))

Atlas Genet Cytogenet Oncol Haematol. 2008-11-01

Online version: http://atlasgeneticsoncology.org/gene/44342/css/haematological-explorer/tumors-explorer/