GPR30 is an estrogen-responsive GPCR (7-transmembrane G protein-coupled receptor).

The open reading frame of GPR30 is encoded by a single exon (1125 bp) located at chromosome 7p22.3.

GPR30 mRNA is about 3.0 kb in human with an 1125 bp open reading frame.

The gene encodes a 7-transmembrane G protein-coupled receptor (GPCR) of 375 amino acids.

GPR30 is widely express throughout the body.

Predominantly in the Endoplasmic Reticulum.

Rapid and transcriptional responses to estrogen.
GPR30 is a 7-transmembrane G protein-coupled receptor (GPCR) that has been shown to be an estrogen responsive receptor, expressed predominantly in the endoplasmic reticulum. Signaling occurs via heterotrimeric G protein activation resulting in matrix-metalloproteinase activation, release of heparin-binding EGF and transactivation of EGFR with subsequent MAPK and Akt activation. Calcium mobilization has also been reported in multiple cell types including neurons. This protein plays a role in the rapid non-genomic signaling events often seen following stimulation with estrogen. Transcriptional activation has also been reported secondary to kinase activation. Actions of GPR30 can occur in parallel to those mediated by ERalpha and ERbeta in cells where multiple receptor are expressed, or in the absence of ERalpha and ERbeta. Note that GPR30 does not appear to mediate transcription via classical estrogen-response elements.

High homology between species. Low homology to other GPCRs.

None