BOP1 (block of proliferation 1)

2008-10-01   Audrey Killian  , Richard Sesboüé  

INSERM U614, Faculté de Médecine-Pharmacie de Rouen, 22 boulevard Gambetta, 76183 ROUEN Cedex 1, France

Identity

HGNC
BOP1
LOCATION
8q24.3
LOCUSID
23246
ALIAS
-
FUSION GENES
Show Gene Fusions

DNA/RNA

Atlas Image
A: Genomic structure of BOP1: the gene extends over 29kb with 16 exons (lower part). Exons 4-16 (upper part) are clustered in 2.6 kb while exons 1-3 are separated by large (2-12 kb) introns.

Description

The BOP1 gene is situated 16.6 Mb downstream from the MYC proto-oncogene (8q24.21) and 0.8 Mb upstream from the telomere (Fig1B).

Transcription

BOP1 mRNA (NM_015201) has a size of 2422 bp.

Pseudogene

No pseudogene has been reported for BOP1, but the NCBI Map viewer (Build 36.3) displays a perfect match encompassing exons 4-16, 64kb centromeric to the gene.

Proteins

Atlas Image
Position of the WD repeats.

Description

The Ribosome biogenesis protein BOP1 consists of 746 amino acids and has a molecular weight of 83.63 kDa. It contains 7 WD repeats.

Expression

BOP1 is expressed ubiquitously and found in nearly all tissues at similar levels.

Localisation

Nucleus, nucleolus.

Function

Required for maturation of the 25S and 5.8S ribosomal RNAs. Essential for cell proliferation. Involved in chromosomal segregation.

Homology

Mus musculus Bop1; Rattus norvegicus Bop1; Equus caballus BOP1; Bos taurus BOP1

Mutations

Note

None described to date.

Implicated in

Entity name
Colorectal cancer
Note
A copy number increase of the BOP1 gene was detected in 39% of colorectal cancer samples (n=56) and was associated with an increase of its mRNA level. This copy number increase was more frequent than that observed for MYC, a proto-oncogene located 16.6 Mb upstream from BOP1 and was distinct from MYC amplification in 16% of the cases.

Transient overexpression of BOP1 in human cells increased the percentage of abnormal mitoses with multipolar spindles.

Article Bibliography

Pubmed IDLast YearTitleAuthors

Other Information

Locus ID:

NCBI: 23246
MIM: 610596
HGNC: 15519
Ensembl: ENSG00000261236

Variants:

dbSNP: 23246
ClinVar: 23246
TCGA: ENSG00000261236
COSMIC: BOP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000261236ENST00000569403A0A075B729
ENSG00000261236ENST00000569669Q14137

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Gene ExpressionREACTOMER-HSA-74160
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
376153702023PDGF-C promotes cell proliferation partially via downregulating BOP1.0
376813362023BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway.0
376153702023PDGF-C promotes cell proliferation partially via downregulating BOP1.0
376813362023BOP1 Promotes Prostate Cancer through the DUSP6/MAPK Pathway.0
330393512021Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.6
335108382021BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis.5
337977542021BOP1 confers chemoresistance of triple-negative breast cancer by promoting CBP-mediated β-catenin acetylation.14
338775442021BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation.4
330393512021Expression, Localization, and Function of the Nucleolar Protein BOP1 in Prostate Cancer Progression.6
335108382021BOP1 Knockdown Attenuates Neointimal Hyperplasia by Activating p53 and Inhibiting Nascent Protein Synthesis.5
337977542021BOP1 confers chemoresistance of triple-negative breast cancer by promoting CBP-mediated β-catenin acetylation.14
338775442021BOP1 Silencing Suppresses Gastric Cancer Proliferation through p53 Modulation.4
321676162020Block of proliferation 1 promotes cell migration and invasion in human colorectal cancer cells via the JNK pathway.7
328052812020The Long Noncoding RNA CCAT2 Induces Chromosomal Instability Through BOP1-AURKB Signaling.55
321676162020Block of proliferation 1 promotes cell migration and invasion in human colorectal cancer cells via the JNK pathway.7

Citation

Audrey Killian ; Richard Sesboüé

BOP1 (block of proliferation 1)

Atlas Genet Cytogenet Oncol Haematol. 2008-10-01

Online version: http://atlasgeneticsoncology.org/gene/44348/gene-explorer/gene-fusions-explorer/meetings/