JUP (junction plakoglobin)

2003-11-01  

Identity

HGNC
JUP
LOCATION
17q21.2
LOCUSID
3728
ALIAS
CTNNG,DP3,DPIII,PDGB,PG,PKGB
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3728
MIM: 173325
HGNC: 6207
Ensembl: ENSG00000173801

Variants:

dbSNP: 3728
ClinVar: 3728
TCGA: ENSG00000173801
COSMIC: JUP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000173801ENST00000310706P14923
ENSG00000173801ENST00000310706A0A0S2Z487
ENSG00000173801ENST00000393930P14923
ENSG00000173801ENST00000393930A0A0S2Z487
ENSG00000173801ENST00000393931P14923
ENSG00000173801ENST00000393931A0A0S2Z487
ENSG00000173801ENST00000420370C9J826
ENSG00000173801ENST00000424457C9JTX4
ENSG00000173801ENST00000437187C9JK18
ENSG00000173801ENST00000437369C9JPI2
ENSG00000173801ENST00000449889C9JKY1
ENSG00000173801ENST00000591690K7ERP3

Expression (GTEx)

0
500
1000
1500
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Acute myeloid leukemiaKEGGko05221
Pathways in cancerKEGGhsa05200
Acute myeloid leukemiaKEGGhsa05221
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGko05412
Arrhythmogenic right ventricular cardiomyopathy (ARVC)KEGGhsa05412
Transcriptional misregulation in cancerKEGGko05202
Transcriptional misregulation in cancerKEGGhsa05202
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
Signal TransductionREACTOMER-HSA-162582
Signaling by VEGFREACTOMER-HSA-194138
VEGFA-VEGFR2 PathwayREACTOMER-HSA-4420097
VEGFR2 mediated vascular permeabilityREACTOMER-HSA-5218920
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Adherens junctions interactionsREACTOMER-HSA-418990
Developmental BiologyREACTOMER-HSA-1266738
Neutrophil degranulationREACTOMER-HSA-6798695
KeratinizationREACTOMER-HSA-6805567
Formation of the cornified envelopeREACTOMER-HSA-6809371

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
383679152024Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signaling pathway.1
383679152024Plakoglobin regulates adipocyte differentiation independently of the Wnt/β-catenin signaling pathway.1
374099712023TRIM50 Inhibits Gastric Cancer Progression by Regulating the Ubiquitination and Nuclear Translocation of JUP.2
374099712023TRIM50 Inhibits Gastric Cancer Progression by Regulating the Ubiquitination and Nuclear Translocation of JUP.2
350785072022KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway.18
360367682022ICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF-κB signaling pathway.2
360437872022Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB.1
350785072022KRT13 promotes stemness and drives metastasis in breast cancer through a plakoglobin/c-Myc signaling pathway.18
360367682022ICAT promotes colorectal cancer metastasis via binding to JUP and activating the NF-κB signaling pathway.2
360437872022Plakoglobin and High-Mobility Group Box 1 Mediate Intestinal Epithelial Cell Apoptosis Induced by Clostridioides difficile TcdB.1
335331272021Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets.5
335916362021Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma.5
347453852021Ral GEF with the PH Domain and SH3 Binding Motif 1 Regulated by Splicing Factor Junction Plakoglobin and Pyrimidine Metabolism Are Prognostic in Uterine Carcinosarcoma.1
335331272021Opposing prognostic relevance of junction plakoglobin in distinct prostate cancer patient subsets.5
335916362021Junction plakoglobin regulates and destabilizes HIF2α to inhibit tumorigenesis of renal cell carcinoma.5

Citation

Dessen P

JUP (junction plakoglobin)

Atlas Genet Cytogenet Oncol Haematol. 2003-11-01

Online version: http://atlasgeneticsoncology.org/gene/449/gene-fusions/favicon/meetings/