IL11 (interleukin 11)

2007-02-01  

Identity

HGNC
IL11
LOCATION
19q13.42
LOCUSID
3589
ALIAS
AGIF,IL-11
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3589
MIM: 147681
HGNC: 5966
Ensembl: ENSG00000095752

Variants:

dbSNP: 3589
ClinVar: 3589
TCGA: ENSG00000095752
COSMIC: IL11

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000095752ENST00000264563P20809
ENSG00000095752ENST00000264563A8K3F7
ENSG00000095752ENST00000585513P20809
ENSG00000095752ENST00000585513A8K3F7
ENSG00000095752ENST00000587093K7ESD5
ENSG00000095752ENST00000590625P20809

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Jak-STAT signaling pathwayKEGGko04630
Hematopoietic cell lineageKEGGko04640
Cytokine-cytokine receptor interactionKEGGhsa04060
Jak-STAT signaling pathwayKEGGhsa04630
Hematopoietic cell lineageKEGGhsa04640
Rheumatoid arthritisKEGGko05323
Rheumatoid arthritisKEGGhsa05323
Immune SystemREACTOMER-HSA-168256
Cytokine Signaling in Immune systemREACTOMER-HSA-1280215
Signaling by InterleukinsREACTOMER-HSA-449147
Interleukin-6 family signalingREACTOMER-HSA-6783589
IL-6-type cytokine receptor ligand interactionsREACTOMER-HSA-6788467

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA10074escitalopramChemicalClinicalAnnotationassociatedPD23142150
PA447278DepressionDiseaseClinicalAnnotationassociatedPD23142150
PA449015citalopramChemicalMultilinkAnnotationassociated25916525

References

Pubmed IDYearTitleCitations
384298452024Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.0
384550572024IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.0
386438172024Serum levels of IL-9 and IL-11 serve as predictors for the occurrence of early neurologic deterioration in patients with cerebral infarction.0
386794152024Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.0
384298452024Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway.0
384550572024IL11-mediated stromal cell activation may not be the master regulator of pro-fibrotic signaling downstream of TGFβ.0
386438172024Serum levels of IL-9 and IL-11 serve as predictors for the occurrence of early neurologic deterioration in patients with cerebral infarction.0
386794152024Targeting IL-11 to reduce fibrocyte circulation and lung accumulation in animal models of pulmonary hypertension-associated lung fibrosis.0
365213732023Anti-apoptosis effect of recombinant human interleukin-11 in neonatal hypoxic-ischemic rats through activating the IL-11Rα/STAT3 signaling pathway.1
367588592023IL-11 drives the phenotypic transformation of tracheal epithelial cells and fibroblasts to enhance abnormal repair after tracheal injury.3
368347782023The Interleukin-11/IL-11 Receptor Promotes Glioblastoma Survival and Invasion under Glucose-Starved Conditions through Enhanced Glutaminolysis.2
369767352023[Interleukin-11 in Pathologies of the Nervous System].1
371537322023IL11 signaling mediates piR-2158 suppression of cell stemness and angiogenesis in breast cancer.6
372917922023Elevated interleukin-11 in systemic sclerosis and role in disease pathogenesis.4
374016652023Blockade of IL-11 Trans-Signaling or JAK2/STAT3 Signaling Ameliorates the Profibrotic Effect of IL-11.2

Citation

Dessen P

IL11 (interleukin 11)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45534/favicon/deep-insight-explorer/