ADGRA2 (adhesion G protein-coupled receptor A2)

2007-02-01  

Identity

HGNC
ADGRA2
LOCATION
8p11.23
LOCUSID
25960
ALIAS
GPR124,TEM5
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 25960
MIM: 606823
HGNC: 17849
Ensembl: ENSG00000020181

Variants:

dbSNP: 25960
ClinVar: 25960
TCGA: ENSG00000020181
COSMIC: ADGRA2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000020181ENST00000315215Q96PE1
ENSG00000020181ENST00000412232Q96PE1
ENSG00000020181ENST00000428068H7C1L1

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
376945342024Down-regulated Wnt7a and GPR124 in early-onset preeclampsia placentas reduce invasion and migration of trophoblast cells.0
376945342024Down-regulated Wnt7a and GPR124 in early-onset preeclampsia placentas reduce invasion and migration of trophoblast cells.0
356493602022An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates.5
356493602022An integrated model for Gpr124 function in Wnt7a/b signaling among vertebrates.5
329910492021Variants of WNT7A and GPR124 are associated with hemorrhagic transformation following intravenous thrombolysis in ischemic stroke.11
329910492021Variants of WNT7A and GPR124 are associated with hemorrhagic transformation following intravenous thrombolysis in ischemic stroke.11
310583652019GPR124 regulates microtubule assembly, mitotic progression, and glioblastoma cell proliferation.10
313522222019Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients.5
310583652019GPR124 regulates microtubule assembly, mitotic progression, and glioblastoma cell proliferation.10
313522222019Serum TEM5 and TEM7 concentrations correlate with clinicopathologic features and poor prognosis of colorectal cancer patients.5
286003582017Cell adhesion controlled by adhesion G protein-coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo-Dock.14
286003582017Cell adhesion controlled by adhesion G protein-coupled receptor GPR124/ADGRA2 is mediated by a protein complex comprising intersectins and Elmo-Dock.14
245827492014miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124.60
245827492014miR-138-5p reverses gefitinib resistance in non-small cell lung cancer cells via negatively regulating G protein-coupled receptor 124.60
220138972012Thrombin-induced shedding of tumour endothelial marker 5 and exposure of its RGD motif are regulated by cell-surface protein disulfide-isomerase.9

Citation

Dessen P

ADGRA2 (adhesion G protein-coupled receptor A2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45576/tumors-explorer/js/lib/haematological-explorer/