UNC5C (unc-5 netrin receptor C)

2007-02-01  

Identity

HGNC
UNC5C
LOCATION
4q22.3
LOCUSID
8633
ALIAS
UNC5H3
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 8633
MIM: 603610
HGNC: 12569
Ensembl: ENSG00000182168

Variants:

dbSNP: 8633
ClinVar: 8633
TCGA: ENSG00000182168
COSMIC: UNC5C

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000182168ENST00000453304O95185
ENSG00000182168ENST00000504962D6RE16
ENSG00000182168ENST00000506749O95185
ENSG00000182168ENST00000513796E0CX15
ENSG00000182168ENST00000610318A0A087X152

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Axon guidanceKEGGhsa04360
Developmental BiologyREACTOMER-HSA-1266738
Axon guidanceREACTOMER-HSA-422475
Netrin-1 signalingREACTOMER-HSA-373752
Netrin mediated repulsion signalsREACTOMER-HSA-418886

References

Pubmed IDYearTitleCitations
385403642024UNC5C: Novel Gene Associated with Psychiatric Disorders Impacts Dysregulation of Axon Guidance Pathways.0
385403642024UNC5C: Novel Gene Associated with Psychiatric Disorders Impacts Dysregulation of Axon Guidance Pathways.0
357099262022Identification and validation of HOXD3 and UNC5C as molecular signatures in keloid based on weighted gene co-expression network analysis.1
357099262022Identification and validation of HOXD3 and UNC5C as molecular signatures in keloid based on weighted gene co-expression network analysis.1
337061302021A global integrated analysis of UNC5C down-regulation in cancers: insights from mechanism and combined treatment strategy.4
337061302021A global integrated analysis of UNC5C down-regulation in cancers: insights from mechanism and combined treatment strategy.4
317893892020UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway.7
317893892020UNC5C‑knockdown enhances the growth and metastasis of breast cancer cells by potentiating the integrin α6/β4 signaling pathway.7
308833452019An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults.5
308833452019An UNC5C Allele Predicts Cognitive Decline and Hippocampal Atrophy in Clinically Normal Older Adults.5
298013992018Significant Pattern of Promoter Hypermethylation of UNC5C Gene in Colorectal Cancer and Its Implication in Late Stage Disease.5
298013992018Significant Pattern of Promoter Hypermethylation of UNC5C Gene in Colorectal Cancer and Its Implication in Late Stage Disease.5
283786352017Methylation of the UNC5C gene and its protein expression in colorectal cancer.5
284414262017Identification of genes associated with dissociation of cognitive performance and neuropathological burden: Multistep analysis of genetic, epigenetic, and transcriptional data.60
283786352017Methylation of the UNC5C gene and its protein expression in colorectal cancer.5

Citation

Dessen P

UNC5C (unc-5 netrin receptor C)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45616/js/css/tumors-explorer/