GPR143 (G protein-coupled receptor 143)

2007-02-01 Affiliation

Identity

HGNC

GPR143

LOCATION

Xp22.2

LOCUSID

4935

ALIAS

NYS6,OA1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 4935
MIM: 300808
HGNC: 20145
Ensembl: ENSG00000101850

Variants:

dbSNP: 4935
ClinVar: 4935
TCGA: ENSG00000101850
COSMIC: GPR143

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000101850	ENST00000431126	C9J9N1
ENSG00000101850	ENST00000447366	H7BZN6
ENSG00000101850	ENST00000467482	P51810

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Amine ligand-binding receptors	REACTOME	R-HSA-375280

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
36800996	2023	GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis.	15
37394637	2023	L-DOPA Receptor GPR143 Functionally Couples with Adrenergic α(1B) Receptor at the Second Transmembrane Interface.	0
38222445	2023	GPR143 mutations in an X-linked infantile nystagmus syndrome cohort in Southeast China.	0
36800996	2023	GPR143 controls ESCRT-dependent exosome biogenesis and promotes cancer metastasis.	15
37394637	2023	L-DOPA Receptor GPR143 Functionally Couples with Adrenergic α(1B) Receptor at the Second Transmembrane Interface.	0
38222445	2023	GPR143 mutations in an X-linked infantile nystagmus syndrome cohort in Southeast China.	0
33785018	2021	Identification of a novel GPR143 mutation in a large Chinese family with isolated foveal hypoplasia.	2
34346269	2021	GPR143 genotypic and ocular phenotypic characterisation in a Chinese cohort with ocular albinism.	2
33785018	2021	Identification of a novel GPR143 mutation in a large Chinese family with isolated foveal hypoplasia.	2
34346269	2021	GPR143 genotypic and ocular phenotypic characterisation in a Chinese cohort with ocular albinism.	2
31746431	2020	A novel GPR143 mutation in a Chinese family with X‑linked ocular albinism type 1.	3
31746431	2020	A novel GPR143 mutation in a Chinese family with X‑linked ocular albinism type 1.	3
31574285	2019	Evaluation of the iris thickness changes for the Chinese families with GPR143 gene mutations.	2
31884582	2019	GPR143 Signaling and Retinal Degeneration.	6
31574285	2019	Evaluation of the iris thickness changes for the Chinese families with GPR143 gene mutations.	2

Citation

Dessen P

GPR143 (G protein-coupled receptor 143)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45630/js/gene-fusions-explorer/