PELP1 (proline, glutamate and leucine rich protein 1)

2007-02-01  

Identity

HGNC
LOCATION
17p13.2
LOCUSID
ALIAS
MNAR,P160
FUSION GENES

Other Information

Locus ID:

NCBI: 27043
MIM: 609455
HGNC: 30134
Ensembl: ENSG00000141456

Variants:

dbSNP: 27043
ClinVar: 27043
TCGA: ENSG00000141456
COSMIC: PELP1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141456ENST00000301396C9JFV4
ENSG00000141456ENST00000436683E7EV54
ENSG00000141456ENST00000570387I3L4P1
ENSG00000141456ENST00000570571I3L445
ENSG00000141456ENST00000572293Q8IZL8
ENSG00000141456ENST00000572293C9JFV4
ENSG00000141456ENST00000574876Q8IZL8
ENSG00000141456ENST00000575101I3L1P4
ENSG00000141456ENST00000575329I3L4M7

Expression (GTEx)

0
10
20
30
40
50
60
70

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Gene ExpressionREACTOMER-HSA-74160
Signaling by PTK6REACTOMER-HSA-8848021
PTK6 ExpressionREACTOMER-HSA-8849473
rRNA processingREACTOMER-HSA-72312
Major pathway of rRNA processing in the nucleolus and cytosolREACTOMER-HSA-6791226
rRNA processing in the nucleus and cytosolREACTOMER-HSA-8868773

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
365778842023Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality.1
371599182023PELP1 and SRC kinase as important molecules in the estrogen-mediated pathway in human testis and epididymis.0
365778842023Expression of estrogen receptors, PELP1, and SRC in human spermatozoa and their associations with semen quality.1
371599182023PELP1 and SRC kinase as important molecules in the estrogen-mediated pathway in human testis and epididymis.0
359699402022PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug.2
359699402022PELP1 is overexpressed in lung cancer and promotes tumor cell malignancy and resistance to tyrosine kinase inhibitor drug.2
332695402021Interaction of transcription factor AP-2 gamma with proto-oncogene PELP1 promotes tumorigenesis by enhancing RET signaling.14
336075892021PELP1 promotes the expression of RUNX2 via the ERK pathway during the osteogenic differentiation of human periodontal ligament stem cells.0
341036812021PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER(+) breast cancer.13
342575302021Overexpression of PELP1 in Lung Adenocarcinoma Promoted E(2) Induced Proliferation, Migration and Invasion of the Tumor Cells and Predicted a Worse Outcome of the Patients.3
332695402021Interaction of transcription factor AP-2 gamma with proto-oncogene PELP1 promotes tumorigenesis by enhancing RET signaling.14
336075892021PELP1 promotes the expression of RUNX2 via the ERK pathway during the osteogenic differentiation of human periodontal ligament stem cells.0
341036812021PELP1/SRC-3-dependent regulation of metabolic PFKFB kinases drives therapy resistant ER(+) breast cancer.13
342575302021Overexpression of PELP1 in Lung Adenocarcinoma Promoted E(2) Induced Proliferation, Migration and Invasion of the Tumor Cells and Predicted a Worse Outcome of the Patients.3
320374842020Estradiol-Induced MMP-9 Expression via PELP1-Mediated Membrane-Initiated Signaling in ERα-Positive Breast Cancer Cells.7

Citation

Dessen P

PELP1 (proline, glutamate and leucine rich protein 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45632/gene-fusions-explorer/deep-insight-explorer/