FKBP4 (FKBP prolyl isomerase 4)

2007-02-01  

Identity

HGNC
FKBP4
LOCATION
12p13.33
LOCUSID
2288
ALIAS
FKBP51,FKBP52,FKBP59,HBI,Hsp56,PPIase,p52
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 2288
MIM: 600611
HGNC: 3720
Ensembl: ENSG00000004478

Variants:

dbSNP: 2288
ClinVar: 2288
TCGA: ENSG00000004478
COSMIC: FKBP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000004478ENST00000001008Q02790
ENSG00000004478ENST00000538622F5H1U3
ENSG00000004478ENST00000539181H0YFG2
ENSG00000004478ENST00000543769F5H120
ENSG00000004478ENST00000544366H0YG86
ENSG00000004478ENST00000630279F5H120

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Estrogen signaling pathwayKEGGhsa04915
Estrogen signaling pathwayKEGGko04915
Cellular responses to stressREACTOMER-HSA-2262752
Cellular response to heat stressREACTOMER-HSA-3371556
HSF1-dependent transactivationREACTOMER-HSA-3371571
Attenuation phaseREACTOMER-HSA-3371568

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
360670012024FKBP4 correlates with CD8(+) T cells and lymphatic metastases in oral squamous cell carcinoma.0
382038542024Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations.1
360670012024FKBP4 correlates with CD8(+) T cells and lymphatic metastases in oral squamous cell carcinoma.0
382038542024Secretome Analyses Identify FKBP4 as a GBA1-Associated Protein in CSF and iPS Cells from Parkinson's Disease Patients with GBA1 Mutations.1
358492662023E2F Transcription Factor 1 Activates FKBP Prolyl Isomerase 4 to Promote Angiogenesis in Cervical Squamous Cell Carcinoma Via the PI3K/AKT Signaling Pathway.2
365203032023Functions of the Hsp90-Binding FKBP Immunophilins.1
370265262023Impact of FKBP52 on cell proliferation and hormone-dependent cancers.2
372489022023Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies.0
358492662023E2F Transcription Factor 1 Activates FKBP Prolyl Isomerase 4 to Promote Angiogenesis in Cervical Squamous Cell Carcinoma Via the PI3K/AKT Signaling Pathway.2
365203032023Functions of the Hsp90-Binding FKBP Immunophilins.1
370265262023Impact of FKBP52 on cell proliferation and hormone-dependent cancers.2
372489022023Concomitant Neuronal Tau Deposition and FKBP52 Decrease Is an Early Feature of Different Human and Experimental Tauopathies.0
340578122022FKBP51 and FKBP52 regulate androgen receptor dimerization and proliferation in prostate cancer cells.17
353948652022FKBP52 and FKBP51 differentially regulate the stability of estrogen receptor in breast cancer.9
356538272022LncRNA MAFG-AS1 deregulated in breast cancer affects autophagy and progression of breast cancer by interacting with miR-3612 and FKBP4 invitro.7

Citation

Dessen P

FKBP4 (FKBP prolyl isomerase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45694/css/lib/case-report-explorer/