GPX4 (glutathione peroxidase 4)

2007-02-01  

Identity

HGNC
LOCATION
19p13.3
LOCUSID
ALIAS
GPx-4,GSHPx-4,MCSP,PHGPx,SMDS,snGPx,snPHGPx
FUSION GENES

Other Information

Locus ID:

NCBI: 2879
MIM: 138322
HGNC: 4556
Ensembl: ENSG00000167468

Variants:

dbSNP: 2879
ClinVar: 2879
TCGA: ENSG00000167468
COSMIC: GPX4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000167468ENST00000354171P36969
ENSG00000167468ENST00000585362R4GNE4
ENSG00000167468ENST00000585480A0A0A0MTT1
ENSG00000167468ENST00000587648K7ERP4
ENSG00000167468ENST00000588919K7EJ20
ENSG00000167468ENST00000589115K7ENB4
ENSG00000167468ENST00000593032K7EKX7
ENSG00000167468ENST00000611653P36969
ENSG00000167468ENST00000614791A0A087X247
ENSG00000167468ENST00000616066A0A087X2I2
ENSG00000167468ENST00000622390A0A087WT12

Expression (GTEx)

0
500
1000
1500
2000

Pathways

PathwaySourceExternal ID
Glutathione metabolismKEGGko00480
Glutathione metabolismKEGGhsa00480
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Arachidonic acid metabolismREACTOMER-HSA-2142753
Synthesis of 5-eicosatetraenoic acidsREACTOMER-HSA-2142688
Synthesis of 15-eicosatetraenoic acid derivativesREACTOMER-HSA-2142770
Synthesis of 12-eicosatetraenoic acid derivativesREACTOMER-HSA-2142712
FerroptosisKEGGko04216
FerroptosisKEGGhsa04216

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
368281202024FUNDC1 interacts with GPx4 to govern hepatic ferroptosis and fibrotic injury through a mitophagy-dependent manner.13
373446922024Circular RNA 0016142 Knockdown Induces Ferroptosis in Hepatocellular Carcinoma Cells via Modulation of the MicroRNA-188-3p/Glutathione Peroxidase 4 Axis.2
376907332024Ancient dormant virus remnant ERVW-1 drives ferroptosis via degradation of GPX4 and SLC3A2 in schizophrenia.2
378608882024Ubiquitin-specific peptidase 10 attenuates the ferroptosis to promote thyroid cancer malignancy by facilitating GPX4 via elevating SIRT6.1
379681542024Targeting GPX4-mediated Ferroptosis Alleviates Liver Steatosis in a Rat Model of Total Parenteral Nutrition.0
381233652024Ferroptosis-related gene glutathione peroxidase 4 promotes reprogramming of glucose metabolism via Akt-mTOR axis in intrahepatic cholangiocarcinoma.0
381764762024P21 resists ferroptosis in osteoarthritic chondrocytes by regulating GPX4 protein stability.2
381826432024Selenoprotein P expression in glioblastoma as a regulator of ferroptosis sensitivity: preservation of GPX4 via the cycling-selenium storage.0
382287152024GSTM3 enhances radiosensitivity of nasopharyngeal carcinoma by promoting radiation-induced ferroptosis through USP14/FASN axis and GPX4.0
382445932024Circ0060467 sponges miR-6805 to promote hepatocellular carcinoma progression through regulating AIFM2 and GPX4 expression.1
382507612024GPX4 inhibits apoptosis of thyroid cancer cells through regulating the FKBP8/Bcl-2 axis.0
382523172024Selenium-SelK-GPX4 axis protects nucleus pulposus cells against mechanical overloading-induced ferroptosis and attenuates senescence of intervertebral disc.2
383428122024Expression and Significance of BCCIP and Glutathione Peroxidase 4 in Clear Cell Renal Cell Carcinoma.0
384292652024Depletion of the N(6)-Methyladenosine (m6A) reader protein IGF2BP3 induces ferroptosis in glioma by modulating the expression of GPX4.0
384419672024CD8+ T cells sustain antitumor response by mediating crosstalk between adenosine A2A receptor and glutathione/GPX4.1

Citation

Dessen P

GPX4 (glutathione peroxidase 4)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45734/deep-insight-explorer/case-report-explorer/