CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit)

2007-02-01 Affiliation

Identity

HGNC

CHRNA7

LOCATION

15q13.2

LOCUSID

1139

ALIAS

CHRNA7-2,NACHRA7

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 1139
MIM: 118511
HGNC: 1960
Ensembl: ENSG00000175344

Variants:

dbSNP: 1139
ClinVar: 1139
TCGA: ENSG00000175344
COSMIC: CHRNA7

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000175344	ENST00000306901	P36544
ENSG00000175344	ENST00000437966	P36544
ENSG00000175344	ENST00000454250	P36544
ENSG00000175344	ENST00000635722	A0A1B0GVP9
ENSG00000175344	ENST00000635759	A0A1B0GTT0
ENSG00000175344	ENST00000635883	A0A1B0GVN6
ENSG00000175344	ENST00000635884	A0A1B0GTT9
ENSG00000175344	ENST00000635978	A0A1B0GW52
ENSG00000175344	ENST00000636044	A0A1B0GU56
ENSG00000175344	ENST00000636271	A0A1B0GV25
ENSG00000175344	ENST00000636440	A0A1B0GV44
ENSG00000175344	ENST00000636603	A0A1B0GVH2
ENSG00000175344	ENST00000636850	A0A1B0GU93
ENSG00000175344	ENST00000637033	A0A1B0GVH2
ENSG00000175344	ENST00000637183	A0A1B0GV43
ENSG00000175344	ENST00000637348	A0A1B0GTE0
ENSG00000175344	ENST00000637350	A0A1B0GU04
ENSG00000175344	ENST00000637519	A0A1B0GWH1
ENSG00000175344	ENST00000637552	A0A1B0GW47
ENSG00000175344	ENST00000637786	A0A1B0GU93
ENSG00000175344	ENST00000637971	A0A1B0GU11
ENSG00000175344	ENST00000638031	A0A1B0GVI5
ENSG00000175344	ENST00000638081	A0A1B0GUR5
ENSG00000175344	ENST00000638106	A0A1B0GV86

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Cholinergic synapse	KEGG	hsa04725
Nicotine addiction	KEGG	hsa05033
Nicotine addiction	KEGG	ko05033
Chemical carcinogenesis	KEGG	hsa05204
Chemical carcinogenesis	KEGG	ko05204
Neuronal System	REACTOME	R-HSA-112316
Transmission across Chemical Synapses	REACTOME	R-HSA-112315
Neurotransmitter Receptor Binding And Downstream Transmission In The Postsynaptic Cell	REACTOME	R-HSA-112314
Acetylcholine Binding And Downstream Events	REACTOME	R-HSA-181431
Activation of Nicotinic Acetylcholine Receptors	REACTOME	R-HSA-629602
Postsynaptic nicotinic acetylcholine receptors	REACTOME	R-HSA-622327
Highly calcium permeable postsynaptic nicotinic acetylcholine receptors	REACTOME	R-HSA-629594

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PD	PMIDs
PA443319	Alzheimer Disease	Disease	ClinicalAnnotation	associated	PD	24951635
PA449394	donepezil	Chemical	ClinicalAnnotation	associated	PD	24951635
PA449726	galantamine	Chemical	ClinicalAnnotation	associated	PD	24951635
PA450626	nicotine	Chemical	ClinicalAnnotation	associated	PD	20231857
PA451262	rivastigmine	Chemical	ClinicalAnnotation	associated	PD	24951635

References

Pubmed ID	Year	Title	Citations
37640915	2024	Regulation of Inflammation by IRAK-M Pathway Can Be Associated with nAchRalpha7 Activation and COVID-19.	2
38836054	2024	The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein.	0
37640915	2024	Regulation of Inflammation by IRAK-M Pathway Can Be Associated with nAchRalpha7 Activation and COVID-19.	2
38836054	2024	The human alpha7 nicotinic acetylcholine receptor is a host target for the rabies virus glycoprotein.	0
36604774	2023	The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs.	3
36966906	2023	α7 Nicotinic acetylcholine receptor potentiation downregulates chemotherapy-induced inflammatory overactivation by overlapping intracellular mechanisms.	0
36972659	2023	α7 Nicotinic acetylcholine receptors regulate translocation of HIF-1α to the cell nucleus and mitochondria upon hypoxia.	0
36973813	2023	α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect.	7
37295770	2023	Epstein-Barr virus downregulates the α7 nicotinic acetylcholine receptor of CD8(+) T lymphocytes might associate with coronary artery lesions in Kawasaki disease patients.	0
37804592	2023	Crystal structure reveals canonical recognition of the phosphorylated cytoplasmic loop of human alpha7 nicotinic acetylcholine receptor by 14-3-3 protein.	0
36604774	2023	The holistic approach to the CHRNA7 gene, hsa-miR-3158-5p, and 15q13.3 hotspot CNVs in migraineurs.	3
36966906	2023	α7 Nicotinic acetylcholine receptor potentiation downregulates chemotherapy-induced inflammatory overactivation by overlapping intracellular mechanisms.	0
36972659	2023	α7 Nicotinic acetylcholine receptors regulate translocation of HIF-1α to the cell nucleus and mitochondria upon hypoxia.	0
36973813	2023	α7 Nicotinic acetylcholine receptor: a key receptor in the cholinergic anti-inflammatory pathway exerting an antidepressant effect.	7
37295770	2023	Epstein-Barr virus downregulates the α7 nicotinic acetylcholine receptor of CD8(+) T lymphocytes might associate with coronary artery lesions in Kawasaki disease patients.	0

Citation

Dessen P

CHRNA7 (cholinergic receptor nicotinic alpha 7 subunit)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45735/gene-explorer/tumors-explorer/case-report-explorer/