GDI1 (GDP dissociation inhibitor 1)

2007-02-01  

Identity

HGNC
LOCATION
Xq28
LOCUSID
ALIAS
1A,GDIL,MRX41,MRX48,OPHN2,RABGD1A,RABGDIA,XAP-4
FUSION GENES

Other Information

Locus ID:

NCBI: 2664
MIM: 300104
HGNC: 4226
Ensembl: ENSG00000203879

Variants:

dbSNP: 2664
ClinVar: 2664
TCGA: ENSG00000203879
COSMIC: GDI1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000203879ENST00000415109F8WCU0
ENSG00000203879ENST00000434049G5E9U5
ENSG00000203879ENST00000445564F8WE59
ENSG00000203879ENST00000447750P31150
ENSG00000203879ENST00000447750A0A0S2Z3X8
ENSG00000203879ENST00000630693G5E9U5

Expression (GTEx)

0
100
200
300
400
500
600

Pathways

PathwaySourceExternal ID
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
Rho GTPase cycleREACTOMER-HSA-194840
Vesicle-mediated transportREACTOMER-HSA-5653656
Membrane TraffickingREACTOMER-HSA-199991
RAB GEFs exchange GTP for GDP on RABsREACTOMER-HSA-8876198

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
380131212024GDP dissociation inhibitor 1 (GDI1) attenuates β-amyloid-induced neurotoxicity in Alzheimer's diseases.0
380131212024GDP dissociation inhibitor 1 (GDI1) attenuates β-amyloid-induced neurotoxicity in Alzheimer's diseases.0
342521342021The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading.11
345156252021Overexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer.2
342521342021The interplay of Rac1 activity, ubiquitination and GDI binding and its consequences for endothelial cell spreading.11
345156252021Overexpression of GDP dissociation inhibitor 1 gene associates with the invasiveness and poor outcomes of colorectal cancer.2
253461442015Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency.9
256943522015Tumor-specific mutations in low-frequency genes affect their functional properties.8
253461442015Identification of the novel autoantigen candidate Rab GDP dissociation inhibitor alpha in isolated adrenocorticotropin deficiency.9
256943522015Tumor-specific mutations in low-frequency genes affect their functional properties.8
231405042012RabGDI controls axonal midline crossing by regulating Robo1 surface expression.34
231405042012RabGDI controls axonal midline crossing by regulating Robo1 surface expression.34
217360092011Mutations in GDI1 and X-linked non-specific mental retardation.0
220029312011Novel GDI1 mutation in a large family with nonsyndromic X-linked intellectual disability.7
217360092011Mutations in GDI1 and X-linked non-specific mental retardation.0

Citation

Dessen P

GDI1 (GDP dissociation inhibitor 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45753/img/gene-fusions-explorer/case-report-explorer/