BDKRB2 (bradykinin receptor B2)

2007-02-01 Affiliation

Identity

HGNC

BDKRB2

LOCATION

14q32.2

LOCUSID

624

ALIAS

B2R,BK-2,BK2,BKR2,BRB2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 624
MIM: 113503
HGNC: 1030
Ensembl: ENSG00000168398

Variants:

dbSNP: 624
ClinVar: 624
TCGA: ENSG00000168398
COSMIC: BDKRB2

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000168398	ENST00000539359	P30411
ENSG00000168398	ENST00000542454	P30411
ENSG00000168398	ENST00000554311	P30411

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Calcium signaling pathway	KEGG	ko04020
Neuroactive ligand-receptor interaction	KEGG	ko04080
Complement and coagulation cascades	KEGG	ko04610
Regulation of actin cytoskeleton	KEGG	ko04810
Calcium signaling pathway	KEGG	hsa04020
Neuroactive ligand-receptor interaction	KEGG	hsa04080
Complement and coagulation cascades	KEGG	hsa04610
Regulation of actin cytoskeleton	KEGG	hsa04810
Pathways in cancer	KEGG	hsa05200
Chagas disease (American trypanosomiasis)	KEGG	ko05142
Chagas disease (American trypanosomiasis)	KEGG	hsa05142
Endocrine and other factor-regulated calcium reabsorption	KEGG	ko04961
Endocrine and other factor-regulated calcium reabsorption	KEGG	hsa04961
Inflammatory mediator regulation of TRP channels	KEGG	hsa04750
Inflammatory mediator regulation of TRP channels	KEGG	ko04750
cGMP-PKG signaling pathway	KEGG	hsa04022
cGMP-PKG signaling pathway	KEGG	ko04022
Sphingolipid signaling pathway	KEGG	hsa04071
Sphingolipid signaling pathway	KEGG	ko04071
Signal Transduction	REACTOME	R-HSA-162582
Signaling by GPCR	REACTOME	R-HSA-372790
GPCR ligand binding	REACTOME	R-HSA-500792
Class A/1 (Rhodopsin-like receptors)	REACTOME	R-HSA-373076
Peptide ligand-binding receptors	REACTOME	R-HSA-375276
GPCR downstream signaling	REACTOME	R-HSA-388396
G alpha (i) signalling events	REACTOME	R-HSA-418594
G alpha (q) signalling events	REACTOME	R-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPK	REACTOME	R-HSA-881907

Protein levels (Protein atlas)

Not detected

Low

Medium

High

PharmGKB

Entity ID	Name	Type	Evidence	Association	PK	PD	PMIDs
PA164712308	Ace Inhibitors, Plain	Chemical	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	10904024, 11699055, 12522467, 19744011, 21052031, 21832968, 30672376
PA443803	Cough	Disease	ClinicalAnnotation, VariantAnnotation	ambiguous		PD	10904024, 11699055, 12522467, 19744011, 21052031, 21832968, 30672376
PA444552	Hypertension	Disease	ClinicalAnnotation	associated		PD	21052031
PA447288	Essential hypertension	Disease	ClinicalAnnotation	associated		PD	12522467
PA448500	atorvastatin	Chemical	ClinicalAnnotation	associated	PK
PA449456	enalapril	Chemical	ClinicalAnnotation	associated		PD	12522467, 22706620
PA450242	lisinopril	Chemical	ClinicalAnnotation	associated		PD	12522467
PA452640	imidapril	Chemical	ClinicalAnnotation	associated		PD	12522467

References

Pubmed ID	Year	Title	Citations
37703419	2024	Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.	4
37703419	2024	Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.	4
36075965	2023	Function and structure of bradykinin receptor 2 for drug discovery.	6
36075965	2023	Function and structure of bradykinin receptor 2 for drug discovery.	6
35038454	2022	ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors.	8
35132089	2022	Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes.	7
36142237	2022	The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.	1
35038454	2022	ACE2 internalization induced by a SARS-CoV-2 recombinant protein is modulated by angiotensin II type 1 and bradykinin 2 receptors.	8
35132089	2022	Cryo-EM structures of human bradykinin receptor-G(q) proteins complexes.	7
36142237	2022	The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.	1
33412234	2021	Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children.	1
33497625	2021	Potentiation of B2 receptor signaling by AltB2R, a newly identified alternative protein encoded in the human bradykinin B2 receptor gene.	7
33686021	2021	BDKRB2 is a novel EMT-related biomarker and predicts poor survival in glioma.	4
34384552	2021	Association of Variants Near the Bradykinin Receptor B(2) Gene With Angioedema in Patients Taking ACE Inhibitors.	0
33412234	2021	Polymorphism of the bradykinin type 2 receptor gene modulates blood pressure profile and microvascular function in prepubescent children.	1

Citation

Dessen P

BDKRB2 (bradykinin receptor B2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45798/img/case-report-explorer/