LIMS1 (LIM zinc finger domain containing 1)

2007-02-01  

Identity

HGNC
LIMS1
LOCATION
2q12.3
LOCUSID
3987
ALIAS
PINCH,PINCH-1,PINCH1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 3987
MIM: 602567
HGNC: 6616
Ensembl: ENSG00000169756

Variants:

dbSNP: 3987
ClinVar: 3987
TCGA: ENSG00000169756
COSMIC: LIMS1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169756ENST00000332345P48059
ENSG00000169756ENST00000338045P48059
ENSG00000169756ENST00000393310P48059
ENSG00000169756ENST00000409441P48059
ENSG00000169756ENST00000410093P48059
ENSG00000169756ENST00000414829F8WC86
ENSG00000169756ENST00000422797F8WE10
ENSG00000169756ENST00000428064C9JF46
ENSG00000169756ENST00000434274F8WB59
ENSG00000169756ENST00000542845A0A0M3HER1
ENSG00000169756ENST00000544547P48059

Expression (GTEx)

0
5
10
15
20
25
30
35
40
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-extracellular matrix interactionsREACTOMER-HSA-446353
Regulation of cytoskeletal remodeling and cell spreading by IPP complex componentsREACTOMER-HSA-446388

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
386189672024The RNA-binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA.1
386189672024The RNA-binding protein RBMS3 inhibits the progression of colon cancer by regulating the stability of LIMS1 mRNA.1
335294442021A mechanoresponsive PINCH-1-Notch2 interaction regulates smooth muscle differentiation of human placental mesenchymal stem cells.5
335870322021Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.5
338919452021Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.2
335294442021A mechanoresponsive PINCH-1-Notch2 interaction regulates smooth muscle differentiation of human placental mesenchymal stem cells.5
335870322021Complex structures of Rsu1 and PINCH1 reveal a regulatory mechanism of the ILK/PINCH/Parvin complex for F-actin dynamics.5
338919452021Molecular basis for Ras suppressor-1 binding to PINCH-1 in focal adhesion assembly.2
318019732020PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis.9
327469442020Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons.4
327517112020MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.2
330048132020PINCH-1 regulates mitochondrial dynamics to promote proline synthesis and tumor growth.25
318019732020PINCH-1 interacts with myoferlin to promote breast cancer progression and metastasis.9
327469442020Inflammation-induced PINCH expression leads to actin depolymerization and mitochondrial mislocalization in neurons.4
327517112020MicroRNA-Dependent Targeting of RSU1 and the IPP Adhesion Complex Regulates the PTEN/PI3K/AKT Signaling Pathway in Breast Cancer Cell Lines.2

Citation

Dessen P

LIMS1 (LIM zinc finger domain containing 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45926/tumors-explorer/case-report-explorer/