IRX2 (iroquois homeobox 2)

2007-02-01  

Identity

HGNC
IRX2
LOCATION
5p15.33
LOCUSID
153572
ALIAS
IRXA2
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 153572
MIM: 606198
HGNC: 14359
Ensembl: ENSG00000170561

Variants:

dbSNP: 153572
ClinVar: 153572
TCGA: ENSG00000170561
COSMIC: IRX2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000170561ENST00000302057Q9BZI1
ENSG00000170561ENST00000382611Q9BZI1

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
324228642020Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease.3
324228642020Iroquois Homeobox Protein 2 Identified as a Potential Biomarker for Parkinson's Disease.3
260625232015IRX2-mediated upregulation of MMP-9 and VEGF in a PI3K/AKT-dependent manner.8
265604782015Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells.10
260625232015IRX2-mediated upregulation of MMP-9 and VEGF in a PI3K/AKT-dependent manner.8
265604782015Iroquois homeobox 2 suppresses cellular motility and chemokine expression in breast cancer cells.10
248063322014Knockdown of IRX2 inhibits osteosarcoma cell proliferation and invasion by the AKT/MMP9 signaling pathway.10
248063322014Knockdown of IRX2 inhibits osteosarcoma cell proliferation and invasion by the AKT/MMP9 signaling pathway.10
222108792012Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.57
222108792012Gene expression profiles predictive of outcome and age in infant acute lymphoblastic leukemia: a Children's Oncology Group study.57
184210762008A genome-wide scan maps a novel high myopia locus to 5p15.40
184210762008A genome-wide scan maps a novel high myopia locus to 5p15.40
167523832006Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas.15
167523832006Frequent amplifications and abundant expression of TRIO, NKD2, and IRX2 in soft tissue sarcomas.15

Citation

Dessen P

IRX2 (iroquois homeobox 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45962/teaching-explorer/js/lib/tumors-explorer/