THEMIS2 (thymocyte selection associated family member 2)

2007-02-01  

Identity

HGNC
THEMIS2
LOCATION
1p35.3
LOCUSID
9473
ALIAS
C1orf38,ICB-1,ICB1

Other Information

Locus ID:

NCBI: 9473
MIM: 617856
HGNC: 16839
Ensembl: ENSG00000130775

Variants:

dbSNP: 9473
ClinVar: 9473
TCGA: ENSG00000130775
COSMIC: THEMIS2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000130775ENST00000328928Q5TEJ8
ENSG00000130775ENST00000373921Q5TEJ8
ENSG00000130775ENST00000373925Q5TEJ8
ENSG00000130775ENST00000373927Q5TEJ8
ENSG00000130775ENST00000427466Q5TEK2
ENSG00000130775ENST00000442118X6RK39
ENSG00000130775ENST00000456990H7C124

Expression (GTEx)

0
50
100
150
200
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
333891022021Icb-1 expression inhibits growth and fulvestrant response of breast cancer cells and affects survival of breast cancer patients.1
333891022021Icb-1 expression inhibits growth and fulvestrant response of breast cancer cells and affects survival of breast cancer patients.1
248261992014Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer.0
248261992014Icb-1 gene polymorphism rs1467465 is associated with susceptibility to ovarian cancer.0
234744912013icb-1 Gene counteracts growth of ovarian cancer cell lines.3
234744912013icb-1 Gene counteracts growth of ovarian cancer cell lines.3
225658102012Network analysis of icb-1 gene function in human breast cancer cells.2
227325882012Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.24
225658102012Network analysis of icb-1 gene function in human breast cancer cells.2
227325882012Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.24
214555652011Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells.1
214555652011Silencing of the icb-1 gene inhibits the induction of differentiation-associated genes by vitamin D3 and all-trans retinoic acid in gynecological cancer cells.1
199427132010Knockdown of ICB-1 gene enhanced estrogen responsiveness of ovarian and breast cancer cells.2
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.78
205690722010Icb-1 Gene expression is elevated in human endometrial adenocarcinoma and is closely associated with HER2 expression.1

Citation

Dessen P

THEMIS2 (thymocyte selection associated family member 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46069/img/meetings/css/gene-explorer/