LNX1 (ligand of numb-protein X 1)

2007-02-01 Affiliation

Identity

HGNC

LNX1

LOCATION

4q12

LOCUSID

84708

ALIAS

LNX,MPDZ,PDZRN2

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 84708
MIM: 609732
HGNC: 6657
Ensembl: ENSG00000072201

Variants:

dbSNP: 84708
ClinVar: 84708
TCGA: ENSG00000072201
COSMIC: LNX1

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000072201	ENST00000263925	Q8TBB1
ENSG00000072201	ENST00000306888	Q8TBB1
ENSG00000072201	ENST00000507168	D6RE08
ENSG00000072201	ENST00000510143	D6RAH9
ENSG00000072201	ENST00000512247	D6RB76
ENSG00000072201	ENST00000513421	A0A0B4J209

Expression (GTEx)

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Immune System	REACTOME	R-HSA-168256
Adaptive Immune System	REACTOME	R-HSA-1280218
Class I MHC mediated antigen processing & presentation	REACTOME	R-HSA-983169
Antigen processing: Ubiquitination & Proteasome degradation	REACTOME	R-HSA-983168

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
29496391	2018	Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1.	8
29496391	2018	Structure of LNX1:Ubc13~Ubiquitin Complex Reveals the Role of Additional Motifs for the E3 Ligase Activity of LNX1.	8
29190716	2017	Suppression of cancer stemness by upregulating Ligand-of-Numb protein X1 in colorectal carcinoma.	5
29190716	2017	Suppression of cancer stemness by upregulating Ligand-of-Numb protein X1 in colorectal carcinoma.	5
22066909	2012	The ligands of Numb proteins X1 and X2 are specific markers for chronic Q fever.	3
22889411	2012	Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase.	18
22066909	2012	The ligands of Numb proteins X1 and X2 are specific markers for chronic Q fever.	3
22889411	2012	Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase.	18
21104141	2011	A global genomic view on LNX siRNA-mediated cell cycle arrest.	4
22045731	2011	Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis.	14
22087225	2011	Biochemical and computational analysis of LNX1 interacting proteins.	14
21104141	2011	A global genomic view on LNX siRNA-mediated cell cycle arrest.	4
22045731	2011	Ligand of Numb proteins LNX1p80 and LNX2 interact with the human glycoprotein CD8α and promote its ubiquitylation and endocytosis.	14
22087225	2011	Biochemical and computational analysis of LNX1 interacting proteins.	14
19701800	2010	LNX (Ligand of Numb-protein X) interacts with RhoC, both of which regulate AP-1-mediated transcriptional activation.	9

Citation

Dessen P

LNX1 (ligand of numb-protein X 1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46071/img/meetings/case-report-explorer/