CKAP5 (cytoskeleton associated protein 5)

2007-02-01  

Identity

HGNC
CKAP5
LOCATION
11p11.2
LOCUSID
9793
ALIAS
CHTOG,MSPS,TOG,TOGp,ch-TOG
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 9793
MIM: 611142
HGNC: 28959
Ensembl: ENSG00000175216

Variants:

dbSNP: 9793
ClinVar: 9793
TCGA: ENSG00000175216
COSMIC: CKAP5

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000175216ENST00000312055Q14008
ENSG00000175216ENST00000354558Q14008
ENSG00000175216ENST00000525896H0YDX5
ENSG00000175216ENST00000526496E9PQH5
ENSG00000175216ENST00000526876H0YEK7
ENSG00000175216ENST00000527333H0YCF6
ENSG00000175216ENST00000529230Q14008

Expression (GTEx)

0
10
20
30
40
50
60
70
80
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Organelle biogenesis and maintenanceREACTOMER-HSA-1852241
Cilium AssemblyREACTOMER-HSA-5617833
Anchoring of the basal body to the plasma membraneREACTOMER-HSA-5620912
Signal TransductionREACTOMER-HSA-162582
Signaling by Rho GTPasesREACTOMER-HSA-194315
RHO GTPase EffectorsREACTOMER-HSA-195258
RHO GTPases Activate ForminsREACTOMER-HSA-5663220
Cell CycleREACTOMER-HSA-1640170
Cell Cycle, MitoticREACTOMER-HSA-69278
Mitotic G2-G2/M phasesREACTOMER-HSA-453274
G2/M TransitionREACTOMER-HSA-69275
Regulation of PLK1 Activity at G2/M TransitionREACTOMER-HSA-2565942
Centrosome maturationREACTOMER-HSA-380287
Recruitment of mitotic centrosome proteins and complexesREACTOMER-HSA-380270
Loss of proteins required for interphase microtubule organization from the centrosomeREACTOMER-HSA-380284
Loss of Nlp from mitotic centrosomesREACTOMER-HSA-380259
M PhaseREACTOMER-HSA-68886
Mitotic PrometaphaseREACTOMER-HSA-68877
Resolution of Sister Chromatid CohesionREACTOMER-HSA-2500257
Mitotic Metaphase and AnaphaseREACTOMER-HSA-2555396
Mitotic AnaphaseREACTOMER-HSA-68882
Separation of Sister ChromatidsREACTOMER-HSA-2467813
AURKA Activation by TPX2REACTOMER-HSA-8854518

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
384242312024CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments.1
384242312024CKAP5 stabilizes CENP-E at kinetochores by regulating microtubule-chromosome attachments.1
357108762023Competing endogenous RNA analysis reveals the regulatory potency of CKAP5 in HPV+ HNSCC.0
367903702023TACC3-ch-TOG interaction regulates spindle microtubule assembly by controlling centrosomal recruitment of γ-TuRC.3
357108762023Competing endogenous RNA analysis reveals the regulatory potency of CKAP5 in HPV+ HNSCC.0
367903702023TACC3-ch-TOG interaction regulates spindle microtubule assembly by controlling centrosomal recruitment of γ-TuRC.3
349421202022Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity.32
349421202022Circular RNA ZNF609/CKAP5 mRNA interaction regulates microtubule dynamics and tumorigenicity.32
333499592021Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration.33
333499592021Tyrosine phosphorylation regulates hnRNPA2 granule protein partitioning and reduces neurodegeneration.33
333778662020chTOG is a conserved mitotic error correction factor.15
333778662020chTOG is a conserved mitotic error correction factor.15
264144022015Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module.86
264976772015Eribulin targets a ch-TOG-dependent directed migration of cancer cells.13
264144022015Complementary activities of TPX2 and chTOG constitute an efficient importin-regulated microtubule nucleation module.86

Citation

Dessen P

CKAP5 (cytoskeleton associated protein 5)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46139/teaching-explorer/gene-fusions/gene-fusions/?id=46139