BDKRB1 (bradykinin receptor B1)

2007-02-01  

Identity

HGNC
BDKRB1
LOCATION
14q32.2
LOCUSID
623
ALIAS
B1BKR,B1R,BKB1R,BKR1,BRADYB1

Other Information

Locus ID:

NCBI: 623
MIM: 600337
HGNC: 1029
Ensembl: ENSG00000100739

Variants:

dbSNP: 623
ClinVar: 623
TCGA: ENSG00000100739
COSMIC: BDKRB1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100739ENST00000216629P46663
ENSG00000100739ENST00000553356G3V4Y2
ENSG00000100739ENST00000611804P46663

Expression (GTEx)

0
1
2
3
4
5
6
7
8
9
10
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Calcium signaling pathwayKEGGko04020
Neuroactive ligand-receptor interactionKEGGko04080
Complement and coagulation cascadesKEGGko04610
Regulation of actin cytoskeletonKEGGko04810
Calcium signaling pathwayKEGGhsa04020
Neuroactive ligand-receptor interactionKEGGhsa04080
Complement and coagulation cascadesKEGGhsa04610
Regulation of actin cytoskeletonKEGGhsa04810
Pathways in cancerKEGGhsa05200
Inflammatory mediator regulation of TRP channelsKEGGhsa04750
Inflammatory mediator regulation of TRP channelsKEGGko04750
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR ligand bindingREACTOMER-HSA-500792
Class A/1 (Rhodopsin-like receptors)REACTOMER-HSA-373076
Peptide ligand-binding receptorsREACTOMER-HSA-375276
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (i) signalling eventsREACTOMER-HSA-418594
G alpha (q) signalling eventsREACTOMER-HSA-416476
Gastrin-CREB signalling pathway via PKC and MAPKREACTOMER-HSA-881907

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA443796Coronary Artery DiseaseDiseaseClinicalAnnotationassociatedPD20712529
PA450877perindoprilChemicalClinicalAnnotationassociatedPD20712529

References

Pubmed IDYearTitleCitations
377034192024Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.4
377034192024Bradykinin receptor expression and bradykinin-mediated sensitization of human sensory neurons.4
378188532023Bradykinin-bradykinin receptor (B1R) signalling is involved in the blood-brain barrier disruption in moyamoya disease.1
378188532023Bradykinin-bradykinin receptor (B1R) signalling is involved in the blood-brain barrier disruption in moyamoya disease.1
361422372022The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.1
361422372022The Role of Bradykinin Receptors in Hereditary Angioedema Due to C1-Inhibitor Deficiency.1
332844712021Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma.5
332844712021Correlation of matrix-related airway remodeling and bradykinin B1 receptor expression with fixed airflow obstruction in severe asthma.5
320872352020Kinin B1 receptor: A target for neuroinflammation in hypertension.17
320872352020Kinin B1 receptor: A target for neuroinflammation in hypertension.17
301328652019Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells.0
303660002019Bradykinin B1 receptor contributes to interleukin-8 production and glioblastoma migration through interaction of STAT3 and SP-1.18
310174772019The G Allele of the rs12050217 Polymorphism in the BDKRB1 Gene Is Associated with Protection for Diabetic Retinopathy.0
312184442019Interactions between carboxypeptidase M and kinin B1 receptor in endothelial cells.4
301328652019Antitumor activity of cell-penetrant kinin B1 receptor antagonists in human triple-negative breast cancer cells.0

Citation

Dessen P

BDKRB1 (bradykinin receptor B1)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46143/css/lib/case-report-explorer/meetings/