TFPI (tissue factor pathway inhibitor)

2007-02-01  

Identity

HGNC
TFPI
LOCATION
2q32.1
LOCUSID
7035
ALIAS
EPI,LACI,TFI,TFPI1
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 7035
MIM: 152310
HGNC: 11760
Ensembl: ENSG00000003436

Variants:

dbSNP: 7035
ClinVar: 7035
TCGA: ENSG00000003436
COSMIC: TFPI

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000003436ENST00000233156P10646
ENSG00000003436ENST00000339091P10646
ENSG00000003436ENST00000392365P10646
ENSG00000003436ENST00000409676P10646
ENSG00000003436ENST00000417013C9J103
ENSG00000003436ENST00000420747C9JP39
ENSG00000003436ENST00000421427C9JQ14
ENSG00000003436ENST00000435414C9JKV3
ENSG00000003436ENST00000437725C9JQ14
ENSG00000003436ENST00000453013C9JT76

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Complement and coagulation cascadesKEGGko04610
Complement and coagulation cascadesKEGGhsa04610
HemostasisREACTOMER-HSA-109582
Formation of Fibrin Clot (Clotting Cascade)REACTOMER-HSA-140877
Extrinsic Pathway of Fibrin Clot FormationREACTOMER-HSA-140834

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
370301502023Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation.2
376604362023Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation.1
370301502023Endothelial-dependent S-Sulfhydration of tissue factor pathway inhibitor regulates blood coagulation.2
376604362023Activated protein C, protein S, and tissue factor pathway inhibitor cooperate to inhibit thrombin activation.1
352343152022Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood.3
359731912022Mutations of TFPI-binding exosites on factor VII cause bleeding phenotypes in factor VII deficiency.2
352343152022Effects of human TFPI and CD47 expression and selectin and integrin inhibition during GalTKO.hCD46 pig lung perfusion with human blood.3
359731912022Mutations of TFPI-binding exosites on factor VII cause bleeding phenotypes in factor VII deficiency.2
328779532021Relation between Tissue Factor Pathway Inhibitor Activity and Cardiovascular Risk Factors and Diseases in a Large Population Sample.2
334651092021A rare coding mutation in the MAST2 gene causes venous thrombosis in a French family with unexplained thrombophilia: The Breizh MAST2 Arg89Gln variant.3
334967352021Elevated levels of tissue factor pathway inhibitor in patients with mild to moderate bleeding tendency.8
335298862021Circulating Tissue Factor Pathway Inhibitor (TFPI) is increased preceding preeclampsia diagnosis and in established preeclampsia.4
338272542021Major Reservoir for Heparin-Releasable TFPIα (Tissue Factor Pathway Inhibitor α) Is Extracellular Matrix.9
348283312021Single Nucleotide Polymorphisms from CSF2, FLT1, TFPI and TLR9 Genes Are Associated with Prelabor Rupture of Membranes.5
348765222021Intersection of regulatory pathways controlling hemostasis and hemochorial placentation.11

Citation

Dessen P

TFPI (tissue factor pathway inhibitor)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46172/css/lib/case-report-explorer/gene-fusions/?id=46172